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学科主题基础医学
LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis
Yin, Mingzhu1; Xu, Ye1; Lou, Ge1; Hou, Yan2; Meng, Fanling1; Zhang, Haiyu2; Li, Cong3; Zhou, Rouli4
关键词lysosome-associated protein transmembrane 4 immunohistochemistry ovarian carcinoma metastasis
刊名INTERNATIONAL JOURNAL OF CANCER
2011-08-01
DOI10.1002/ijc.25689
129期:3页:629-635
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; CANCER ; PACLITAXEL ; PROTEIN ; TUMORS
英文摘要

LAPTM4B is a novel tumor-associated gene. To date, there have been no published data regarding the role of LAPTM4B expression in epithelial ovarian carcinoma metastasis. Therefore, this study was performed to determine whether LAPTM4B overexpression is a new predictor of epithelial ovarian carcinoma metastasis. LAPTM4B expression was evaluated in 22 normal ovarian specimens and 139 ovarian carcinomas by western blotting analyses and immunohistochemistry. Univariate and multivariate analyses were used to determine the association between LAPTM4B expression and epithelial ovarian carcinoma metastasis. Western blotting analysis demonstrated that LAPTM4B was overexpressed in metastatic tissues from patients with ovarian cancers, and immunohistochemistry results revealed that among 59 patients with LAPTM4B overexpression, 57 (96.6%) presented intraperitoneal metastasis and 31 (52.5%) had lymph node metastasis. The results of the univariate and multivariate analyses demonstrated that LAPTM4B overexpression correlated with metastasis. The odds ratio of high-to-low expression for intraperitoneal metastasis was 11.410 (95% CI: 2.357, 55.239) and that for lymph node metastasis was 6.332 (95% CI: 2.533, 15.831). For intraperitoneal metastasis, the sensitivity and specificity of LAPTM4B overexpression were 48.7% and 90.9%; for lymph node metastasis, they were 73.8%% and 71.1%, respectively. LAPTM4B overexpression is a new predictor of epithelial ovarian carcinoma metastasis and an important potential biomarker for the early diagnosis of ovarian carcinoma.

语种英语
WOS记录号WOS:000291606000012
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被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62692
专题北京大学基础医学院_细胞生物学系
作者单位1.Harbin Med Univ, Dept Gynecol Oncol, Tumor Hosp, Harbin 150081, Peoples R China
2.Harbin Med Univ, Dept Biostat, Harbin 150081, Peoples R China
3.Harbin Med Univ, Dept Pathol, Tumor Hosp, Harbin 150081, Peoples R China
4.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
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Yin, Mingzhu,Xu, Ye,Lou, Ge,et al. LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis[J]. INTERNATIONAL JOURNAL OF CANCER,2011,129(3):629-635.
APA Yin, Mingzhu.,Xu, Ye.,Lou, Ge.,Hou, Yan.,Meng, Fanling.,...&Zhou, Rouli.(2011).LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis.INTERNATIONAL JOURNAL OF CANCER,129(3),629-635.
MLA Yin, Mingzhu,et al."LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis".INTERNATIONAL JOURNAL OF CANCER 129.3(2011):629-635.
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