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学科主题: 口腔医学
题名:
Relationship between vitamin D receptor gene polymorphism and periodontitis
作者: Sun, JL; Meng, HX; Cao, CF; Tachi, Y; Shinohara, M; Ueda, M; Imai, H; Ohura, K
关键词: polymorphism ; periodontitis ; susceptibility ; VDR gene
刊名: JOURNAL OF PERIODONTAL RESEARCH
发表日期: 2002-08-01
卷: 37, 期:4, 页:263-267
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: EARLY-ONSET PERIODONTITIS ; MESSENGER-RNA STABILITY ; D-RESISTANT RICKETS ; GENOTYPE ; ASSOCIATION ; INHERITANCE ; MUTATION ; CHINESE ; DENSITY
英文摘要:

Recent studies have shown that vitamin D receptor (VDR) gene polymorphism had regulatory effects on bone mineral density (BMD) and bone turnover. The VDR gene has also been indicated as a candidate gene for the susceptibility of osteoporosis. However, it is unclear whether VDR genotypes could be associated with alveolar bone loss of patients with periodontitis. or whether vitamin D receptor gene could be a candidate gene for susceptibility to periodontitis. The purpose of this Study was to answer these two questions.

Methods: Twenty-four cases of adult periodontitis (AP). 37 cases of early onset periodontitis (EOP) and 39 healthy controls were recruited for the study. Individual samples of venous blood and DNA were obtained from each subject. Genotypes of the TaqI VDR gene were determined by PCR and TaqI restriction endonuclease digestion.

Results: One out of 24 AP patients, nine out of 37 EOP patients and two out of 39 healthy controls were detected with Tt genotype, while the rest had the TT genotype. The detected frequency of Tt genotype was significantly higher in EOP patients (24.3%) than in AP patients (4.2%) and healthy controls (5.1%). The frequency of t allele was also significantly higher in EOP patients. There was no statistical difference in the distribution of TaqI VDR genotypes between AP patients and healthy controls. The study suggests that Tt genotype might be a risk indicator for the susceptibility to EOP. Carriage of the allele (t) of the TaqI VDR gene may increase the risk of developing EOP.

语种: 英语
WOS记录号: WOS:000177316600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62710
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Osaka Dent Univ, Dept Pharmacol, Osaka, Japan
2.Osaka Dent Univ, Dept Periodontol, Osaka, Japan
3.Peking Univ, Sch Stomatol, Dept Periodontol, Beijing 100081, Peoples R China

Recommended Citation:
Sun, JL,Meng, HX,Cao, CF,et al. Relationship between vitamin D receptor gene polymorphism and periodontitis[J]. JOURNAL OF PERIODONTAL RESEARCH,2002,37(4):263-267.
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