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学科主题: 公共卫生
题名:
MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro
作者: Huang, Hongpeng1,2; Tang, Qiuqiong1,2; Chu, Hongqian1,2; Jiang, Jianjun1,2; Zhang, Haizhou3; Hao, Weidong1,2; Wei, Xuetao1,2
关键词: CD4(+) T cells ; MAP4K4 ; PKC-theta ; Treg
刊名: CELLULAR IMMUNOLOGY
发表日期: 2014-05-01
DOI: 10.1016/j.cellimm.2014.02.006
卷: 289, 期:1-2, 页:15-20
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: PROTEIN-KINASE-C ; NF-KAPPA-B ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; PKC-THETA ; SIGNAL-TRANSDUCTION ; IMMUNE-RESPONSE ; IL-2 PROMOTER ; LYMPHOCYTES ; PATHWAYS ; COSTIMULATION
英文摘要:

CD4(+) T cells are critical for adaptive immunity. MAP4K4 is a key member of germinal center kinase group. However, the physiological function of MAP4K4 in primary CD4(+) T cells is still unclear. In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis. Additionally, MAP4K4 was required for the activation of CD4(+) T cells. MAP4K4 deletion significantly down-regulated expression of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma), while notably upregulating the expression of regulatory T cells (Treg) transcription factor Foxp3 in peripheral CD4(+) T cells. Furthermore, western blot analysis indicated that CD4(+) T cells lacking MAP4K4 failed to phosphorylate Jnk, Erk, p38 and PKC-theta. Thus, our results provide the evidence that MAP4K4 is essential for CD4(+) T cell proliferation, activation and cytokine production. (c) 2014 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000337120900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62711
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.Roche R&D Ctr China Ltd, Shanghai 201203, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Hongpeng,Tang, Qiuqiong,Chu, Hongqian,et al. MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro[J]. CELLULAR IMMUNOLOGY,2014,289(1-2):15-20.
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