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MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro
Huang, Hongpeng1,2; Tang, Qiuqiong1,2; Chu, Hongqian1,2; Jiang, Jianjun1,2; Zhang, Haizhou3; Hao, Weidong1,2; Wei, Xuetao1,2
关键词CD4(+) T cells MAP4K4 PKC-theta Treg
刊名CELLULAR IMMUNOLOGY
2014-05-01
DOI10.1016/j.cellimm.2014.02.006
289期:1-2页:15-20
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]PROTEIN-KINASE-C ; NF-KAPPA-B ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; PKC-THETA ; SIGNAL-TRANSDUCTION ; IMMUNE-RESPONSE ; IL-2 PROMOTER ; LYMPHOCYTES ; PATHWAYS ; COSTIMULATION
英文摘要

CD4(+) T cells are critical for adaptive immunity. MAP4K4 is a key member of germinal center kinase group. However, the physiological function of MAP4K4 in primary CD4(+) T cells is still unclear. In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis. Additionally, MAP4K4 was required for the activation of CD4(+) T cells. MAP4K4 deletion significantly down-regulated expression of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma), while notably upregulating the expression of regulatory T cells (Treg) transcription factor Foxp3 in peripheral CD4(+) T cells. Furthermore, western blot analysis indicated that CD4(+) T cells lacking MAP4K4 failed to phosphorylate Jnk, Erk, p38 and PKC-theta. Thus, our results provide the evidence that MAP4K4 is essential for CD4(+) T cell proliferation, activation and cytokine production. (c) 2014 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000337120900003
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62711
专题北京大学公共卫生学院_公共卫生学院
北京大学公共卫生学院_毒理学系
作者单位1.Roche R&D Ctr China Ltd, Shanghai 201203, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
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GB/T 7714
Huang, Hongpeng,Tang, Qiuqiong,Chu, Hongqian,et al. MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro[J]. CELLULAR IMMUNOLOGY,2014,289(1-2):15-20.
APA Huang, Hongpeng.,Tang, Qiuqiong.,Chu, Hongqian.,Jiang, Jianjun.,Zhang, Haizhou.,...&Wei, Xuetao.(2014).MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro.CELLULAR IMMUNOLOGY,289(1-2),15-20.
MLA Huang, Hongpeng,et al."MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro".CELLULAR IMMUNOLOGY 289.1-2(2014):15-20.
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