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ADVANCES IN THE FIRST TOTAL SYNTHESIS OF NATURAL FLAVONOIDS
Wang, Zhonglei1; Yang, Liyan2; Yang, Xiuwei3; Zhang, Xiaohua1
关键词Biological activity first total synthesis flavonoid natural products
刊名SYNTHETIC COMMUNICATIONS
2013-12-02
DOI10.1080/00397911.2013.820835
43期:23页:3093-3114
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CYTOTOXIC FLAVONOIDS ; BIOLOGICAL-ACTIVITY ; STEM BARK ; IN-VITRO ; ISOFLAVONES ; CONSTITUENTS ; PSOROSPERMIN ; BIFLAVONOIDS ; COMPONENT ; APOPTOSIS
英文摘要

Flavonoids, composed of a C-6-C-3-C-6 backbone, are a kind of secondary metabolites of natural medicine, which widely exist in the higher plant. They have received extensive attention from all over the world and obtained rapid development owing to widespread distribution, structural complexity, active diversity, and molecular plasticity. Total synthesis of natural products is not only one of the most driving forces in organic chemistry but also the embodiment of the development level of organic synthesis chemistry. Total synthesis research possesses not only important theoretical significance to the development of organic chemistry but also potential marketing prospects to clinical medicine and significant practical value to the development of natural medicine. Flavonoids contain flavan, chalcone, flavone, biflavone, isoflavone, xanthone, pterocarpin, homoisoflavone, flavonol, favonolignan, and some other main structure types. This article summarizes the latest research on first total synthesis, including the plant sources and biological activities, of these main structure types, so as to provide some reference for both the research of first total synthesis of natural flavonoids and the development and utilization of their medicinal value.

语种英语
WOS记录号WOS:000329425400001
项目编号2011ZX05009-005
资助机构National Science and Technology Major Project
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62720
专题北京大学药学院
作者单位1.China Univ Petr, Coll Sci, Beijing, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 100102, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Zhonglei,Yang, Liyan,Yang, Xiuwei,et al. ADVANCES IN THE FIRST TOTAL SYNTHESIS OF NATURAL FLAVONOIDS[J]. SYNTHETIC COMMUNICATIONS,2013,43(23):3093-3114.
APA Wang, Zhonglei,Yang, Liyan,Yang, Xiuwei,&Zhang, Xiaohua.(2013).ADVANCES IN THE FIRST TOTAL SYNTHESIS OF NATURAL FLAVONOIDS.SYNTHETIC COMMUNICATIONS,43(23),3093-3114.
MLA Wang, Zhonglei,et al."ADVANCES IN THE FIRST TOTAL SYNTHESIS OF NATURAL FLAVONOIDS".SYNTHETIC COMMUNICATIONS 43.23(2013):3093-3114.
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