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学科主题: 临床医学
题名:
Coronary Flow Velocity Reserve is Improved by PPAR- Agonist Fenofibrate in Patients with Hypertriglyceridemia
作者: Wang, Guang1,2,3; He, Liyun2,3; Liu, Jinbo1; Yu, Jie2,3; Feng, Xinheng2,3; Li, Fuwang4; Hao, Yanting2,3; Mao, Jieming2,3; Hong, Tianpei1; Chen, Alex F.5; Wang, Xian4
关键词: Coronary flow velocity reserve ; Endothelial function ; Homocysteine ; PPAR-alpha
刊名: CARDIOVASCULAR THERAPEUTICS
发表日期: 2013-06-01
DOI: 10.1111/j.1755-5922.2011.00307.x
卷: 31, 期:3, 页:161-167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]: Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]: TYPE-2 DIABETES-MELLITUS ; ARTERY ENDOTHELIAL FUNCTION ; PEROXISOME-PROLIFERATOR ; NITRIC-OXIDE ; ATHEROSCLEROSIS ; DISEASE ; ALPHA ; GAMMA ; STIFFNESS ; HYPERHOMOCYSTEINEMIA
英文摘要:

Introduction: Fenofibrate, an agonist of peroxisome proliferator-activated receptor- (PPAR-), has a vascular protective effect. Aims: We investigated the effect of the PPAR- agonist on coronary artery endothelial function in patients with hypertriglyceridemia. Methods: Fifty-eight patients with hypertriglyceridemia were divided into two groups: control (no treatment; n = 23) and fenofibrate treatment (n = 35), 200 mg/d, for 6 months. The patients had undergone rest and adenosine treatment to induce hyperemia for quantification of coronary flow velocity reserve (CFVR) by noninvasive Doppler echocardiography before treatment and at 6-month follow-up. Pulse wave velocity (PWV) was measured before treatment and at 6-month follow-up. Results: CFVR was significantly improved with fenofibrate treatment as compared with baseline level and control group (3.14 +/- 0.36 vs. 2.80 +/- 0.58 and 2.79 +/- 0.65, P < 0.01 and 0.05, respectively), with no difference between baseline levels and untreated controls. In addition, at 6 months, plasma level of homocysteine was significantly increased with fenofibrate treatment as compared with at baseline and control group (median 18.13 [range 14.4622.02]mol/L vs. 14.09 [12.0118.81] and 13.34 [9.6917.06]mol/L, P < 0.001 and 0.01, respectively). Furthermore, at 6 months, PWV was significantly decreased with fenofibrate treatment as compared with control group (1446 +/- 136 cm/s vs. 1570 +/- 203 cm/s, P < 0.05). Conclusions: Treatment with PPAR- agonist fenofibrate significantly improved CFVR and arterial stiffness in patients with hypertriglyceridemia. This endothelial protective effect may be reduced in part by the side effect of increasing homocysteine.

语种: 英语
所属项目编号: 2011CB503904 ; 30730042 ; 30821001 ; 81070701 ; 30770873 ; 81070244
项目资助者: Major National Basic Research Program of P. R. China ; Chinese National Natural Science Foundation
WOS记录号: WOS:000318039100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62722
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
4.Peking Univ, Key Lab Mol Cardiovasc Sci, Dept Physiol & Pathophysiol, Sch Basic Med Sci,Minist Educ,Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Univ Pittsburgh, Dept Surg, Sch Med & Vasc Surg Res, Pittsburgh, PA USA

Recommended Citation:
Wang, Guang,He, Liyun,Liu, Jinbo,et al. Coronary Flow Velocity Reserve is Improved by PPAR- Agonist Fenofibrate in Patients with Hypertriglyceridemia[J]. CARDIOVASCULAR THERAPEUTICS,2013,31(3):161-167.
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