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学科主题: 临床医学
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A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports
作者: Chen, Yongjian; Chen, Guian; Lian, Ying; Gao, Xuefeng; Huang, Jin; Qiao, Jie
关键词: preimplantation genetic diagnosis ; der(15)t(Y ; 15)(q12 ; p11) translocation ; FISH
刊名: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
发表日期: 2007-10-01
DOI: 10.1007/s10815-007-9163-4
卷: 24, 期:10, 页:483-488
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: IN-SITU HYBRIDIZATION ; EXPERIENCE ; EMBRYOS
英文摘要:

Purpose To investigate the clinical application of fluorescence in situ hybridization (FISH) for assessing chromosome disorders of embryos in preimplantation diagnosis of carriers with der(15)t(Y;15)(q12;p11) translocations.

Methods Multicolor FISH was performed using directly-labelled DNA probes, chromosome X with one (DXZ1, Xp11.1-q11.1), but Y with two (DYZ3, Yp11.1-q11.1 and DYZ1, Yq12). Normal embryos were transferred on day 6 at blastocyst stage.

Results Couple A: Three of 6 biopsied embryos were normal. Two normal blastocysts were transferred, but no pregnancy was achieved. Couple B: Three of 6 biopsied embryos were normal. Two normal blastocysts were transferred. A normal male infant weighing 3,230 g was born by cesarean section on the 39th week of gestation. All of the remaining nonreplaced embryos showed mosaic or der(15).

Conclusion Embryos from carries of der(15)t(Y;15)(q12;p11) translocation showed a high frequency of chromosome abnormalities. PGD is a valuable screen tool for those couples to treat their infertility and break the transmission of der(15) chromosome for their offspring.

语种: 英语
WOS记录号: WOS:000250467900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62723
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Yongjian,Chen, Guian,Lian, Ying,et al. A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2007,24(10):483-488.
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