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A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports
Chen, Yongjian; Chen, Guian; Lian, Ying; Gao, Xuefeng; Huang, Jin; Qiao, Jie
关键词preimplantation genetic diagnosis der(15)t(Y 15)(q12 p11) translocation FISH
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2007-10-01
DOI10.1007/s10815-007-9163-4
24期:10页:483-488
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]IN-SITU HYBRIDIZATION ; EXPERIENCE ; EMBRYOS
英文摘要

Purpose To investigate the clinical application of fluorescence in situ hybridization (FISH) for assessing chromosome disorders of embryos in preimplantation diagnosis of carriers with der(15)t(Y;15)(q12;p11) translocations.

Methods Multicolor FISH was performed using directly-labelled DNA probes, chromosome X with one (DXZ1, Xp11.1-q11.1), but Y with two (DYZ3, Yp11.1-q11.1 and DYZ1, Yq12). Normal embryos were transferred on day 6 at blastocyst stage.

Results Couple A: Three of 6 biopsied embryos were normal. Two normal blastocysts were transferred, but no pregnancy was achieved. Couple B: Three of 6 biopsied embryos were normal. Two normal blastocysts were transferred. A normal male infant weighing 3,230 g was born by cesarean section on the 39th week of gestation. All of the remaining nonreplaced embryos showed mosaic or der(15).

Conclusion Embryos from carries of der(15)t(Y;15)(q12;p11) translocation showed a high frequency of chromosome abnormalities. PGD is a valuable screen tool for those couples to treat their infertility and break the transmission of der(15) chromosome for their offspring.

语种英语
WOS记录号WOS:000250467900009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62723
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yongjian,Chen, Guian,Lian, Ying,et al. A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2007,24(10):483-488.
APA Chen, Yongjian,Chen, Guian,Lian, Ying,Gao, Xuefeng,Huang, Jin,&Qiao, Jie.(2007).A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,24(10),483-488.
MLA Chen, Yongjian,et al."A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 24.10(2007):483-488.
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