学科主题临床医学
Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients
Shi, Guangzhi1; Han, Junyan2,3; Liu, Gang4; Hao, Yu2,3; Ma, Yaluan5; Li, Tong2,3; Wu, Xueying2,3; Zhang, Henghui6; Liu, Yanan7; Wang, Beibei2,3; Kong, Yaxian2,3; Zhou, Jianxin1; Zeng, Hui2,3
关键词Bacterial meningitis Cerebrospinal fluid Chemokines Regulatory T (Treg) cells
刊名EUROPEAN JOURNAL OF IMMUNOLOGY
2014-02-01
DOI10.1002/eji.201343572
44期:2页:420-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Natural Science Foundation of China ; 215 program from Beijing Municipal Health Bureau ; National Natural Science Foundation of China ; 215 program from Beijing Municipal Health Bureau
研究领域[WOS]Immunology
关键词[WOS]CEREBROSPINAL-FLUID ; NERVOUS-SYSTEM ; CHEMOTACTIC ACTIVITY ; MONONUCLEAR-CELLS ; SUPPRESSOR-CELLS ; RECRUITMENT ; INFECTION ; CHILDREN ; BARRIER ; MEDIATE
英文摘要

Previous studies have demonstrated that activation/expansion by certain cytokines as well as recruitment by specific chemokines is involved in enrichment of regulatory T(Treg) cells in local tissues or organs under pathological conditions. Recent evidence indicates that human Treg cells are a heterogeneous population that comprises three distinct subpopulations: CD25(+)CD45RA(+) resting Treg (rTreg) cells, CD25(hi)CD45RA(-) activated Treg (aTreg) cells, which are both suppressive, and CD25(+)CD45RA(-) cytokine-secreting Tcells with proinflammatory capacity. Moreover, rTreg cells can proliferate and convert to aTreg cells. Here, we found an increase in aTreg-cell frequency in the cerebrospinal fluid (CSF) of patients with postneurosurgery bacterial meningitis. We revealed that such an increased aTreg-cell frequency in the CSF was not due to enhanced chemotaxis. Instead of a classic conversion pathway from rTreg to aTreg cells, we identified an alternative route of Treg-cell conversion from cytokine-secreting cells to aTreg cells induced by myeloid-specific chemokine CXC chemokine receptor (CXCR) ligand 5 via CXCR1 and CXCR2 receptors, or by CSF myeloid cells in a cell-cell contact manner. Our results reveal a different view of how the immune system controls overwhelming local immune responses during infection, and provide evidence of how innate immunity negatively regulates adaptive immunity.

语种英语
所属项目编号81071587 ; 2009-2-13
资助者National Natural Science Foundation of China ; 215 program from Beijing Municipal Health Bureau ; National Natural Science Foundation of China ; 215 program from Beijing Municipal Health Bureau
WOS记录号WOS:000331901200012
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62725
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Capital Med Univ, Beijing Tiantan Hosp, Intens Care Unit, Beijing 100050, Peoples R China
2.Capital Med Univ, Inst Infect Dis, Beijing Ditan Hosp, Beijing 100015, Peoples R China
3.Beijing Key Lab Emerging Infect Dis, Beijing, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Dept Infect Dis, Beijing, Peoples R China
5.China Acad Chinese Med Sci, Inst Basic Med Theory Chinese Med, Beijing, Peoples R China
6.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100871, Peoples R China
7.Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing, Peoples R China
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GB/T 7714
Shi, Guangzhi,Han, Junyan,Liu, Gang,et al. Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2014,44(2):420-430.
APA Shi, Guangzhi.,Han, Junyan.,Liu, Gang.,Hao, Yu.,Ma, Yaluan.,...&Zeng, Hui.(2014).Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients.EUROPEAN JOURNAL OF IMMUNOLOGY,44(2),420-430.
MLA Shi, Guangzhi,et al."Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients".EUROPEAN JOURNAL OF IMMUNOLOGY 44.2(2014):420-430.
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