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学科主题: 基础医学
题名:
Hesperetin, a Bioflavonoid, Inhibits Rat Aortic Vascular Smooth Muscle Cells Proliferation by Arresting Cell Cycle
作者: Jin, Yong-Ri2; Han, Xiang-Hua1; Zhang, Yong-He3; Lee, Jung-Jin1; Lim, Yong1; Kim, Tack-Joong1; Yoo, Hwan-Soo1; Yun, Yeo-Pyo1
关键词: hesperetin ; bioflavonoid ; p27kip1 ; vascular smooth muscle ; cell cycle
刊名: JOURNAL OF CELLULAR BIOCHEMISTRY
发表日期: 2008-05-01
DOI: 10.1002/jcb.21592
卷: 104, 期:1, 页:1-14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: RECEPTOR TYROSINE-PHOSPHORYLATION ; INTRACELLULAR SIGNAL-TRANSDUCTION ; BB-INDUCED PROLIFERATION ; PDGF-BB ; RETINOBLASTOMA PROTEIN ; HEPATIC CHOLESTEROL ; DEPENDENT KINASES ; DNA-SYNTHESIS ; IN-VIVO ; HESPERIDIN
英文摘要:

Diet can be one of the most important factors that influence for cardiovascular diseases. Hesperetin, a flavonoid present in grapefruits and oranges, is one candidate that may benefit the cardiovascular system. In this study, we have investigated the effect of hesperetin on the platelet-derived growth factor (PDGF)-BB-induced proliferation of primary cultured rate aortic vascular smooth muscle cells (VSMCs). Hesperetin significantly inhibited 50 ng/ml PDGF-BB-induced rat aortic VSMCs proliferation and [H-3]-thymidine incorporation into DNA at concentrations of 5, 25, 50, and 100 mu M. In accordance with these findings, hesperetin revealed blocking of the PDGF-BB-inducible progression through G(0)/G(1) to S phase of the cell cycle in synchronized cells. Western blot showed that hesperetin inhibited not only phosphorylation of retinoblastoma protein (pRb) and expressions of cyclin A, cyclin D, cyclin E, cyclin-dependent kinase 2 (CDK2) as well as proliferating cell nuclear antigen (PCNA) protein, but also downregulation of cyclin-dependent kinase inhibitor (CKI) p(27kip1), while did not affect CKI p21(INK4),p53, and CDK4 expressions as well as early signaling transductions such as PDGF beta-receptor, extracellular signal-regulated kinase (ERK) 1/2, Akt, p38, and JNK phosphorylation. These results suggest that hesperetin inhibits PDGF-BB-induced rat aortic VSMCs proliferation via G(0)/G(1) arrest in association with modulation of the expression or activation of cell-cycle regulatory proteins, which may contribute to the beneficial effect of grapefruits and oranges on cardiovascular system. J. Cell. Biochem. 104: 1-14, 2008. (C) 2007 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000260277000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62731
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Chungbuk Natl Univ, Coll Pharm, Res Ctr Bioresource & Hlth, Cheongju 361763, South Korea
2.Chungbuk Natl Univ, Vet Med Res Inst, Cheongju 361763, South Korea
3.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 110083, Peoples R China

Recommended Citation:
Jin, Yong-Ri,Han, Xiang-Hua,Zhang, Yong-He,et al. Hesperetin, a Bioflavonoid, Inhibits Rat Aortic Vascular Smooth Muscle Cells Proliferation by Arresting Cell Cycle[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2008,104(1):1-14.
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