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学科主题: 临床医学
题名:
Efficacy and safety of glimepiride as initial treatment in Chinese patients with Type 2 diabetes mellitus
作者: Guo, Xiao-hui1; Lv, Xiao-feng2; Han, Ping3; Zhang, Xiu-zhen4; Yang, Hua-zhang5; Duan, Wen-ruo6; Gao, Yan1
关键词: Glimepiride ; Initial treatment ; Type 2 diabetes mellitus
刊名: CURRENT MEDICAL RESEARCH AND OPINION
发表日期: 2013-03-01
DOI: 10.1185/03007995.2013.765396
卷: 29, 期:3, 页:169-174
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]: General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]: PREVALENCE ; SULFONYLUREA ; AGENTS ; NIDDM
英文摘要:

Objective:

To investigate the efficacy and safety of glimepiride as initial mono-therapy in type 2 diabetes patients in China.

Methods:

This is a multi-center, open-label, single arm study. A total of 391 subjects were enrolled to receive glimepiride treatment for 16 weeks, the initiation dose was 1 mg/d, with titration to 2 mg/d and 4 mg/d according to the fasting blood glucose (FBG) level measured at each visit. The change in HbA1c, fasting plasma glucose (FPG), 2 h postprandial blood glucose (2hPPG), HOMA-IR, weight, waist circumference and the incidence of hypoglycemia were evaluated. An exploratory analysis was conducted to identify the potential population prone to achieve target glycemic control.

Results:

HbA1c was reduced significantly from 8.6 +/- 1.6% to 6.9 +/- 0.9% (p<0.001); 60.9% of the subjects achieved HbA1c <7% at study endpoint. The reduction in FPG and 2hPPG were 2.3 mmol/L and 4.4 mmol/L (p<0.001) respectively. Insulin resistance was improved significantly with HOMA-IR decreasing from 2.5 +/- 2.3 to 2.2 +/- 1.9 (p=0.009). The incidence of confirmed hypoglycemia (BG <= 3.9 mmol/L) was 3.1%.

Conclusions:

Glimepiride treatment as initial mono-therapy could effectively improve blood glucose control in type 2 diabetic patients, with a favorable safety profile. Lack of control group was the major limitation of this study.

语种: 英语
项目资助者: Sanofi (China) Investment Co. Ltd. ; Sanofi
WOS记录号: WOS:000314851000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62733
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
2.Beijing PLA, Mil Gen Hosp, Beijing, Peoples R China
3.China Med Univ, Shengjing Hosp, Shenyang, Peoples R China
4.Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China
5.Qingdao Municipal Hosp, Qingdao, Peoples R China
6.Tongji Univ, Tongji Hosp, Sch Med, Shanghai 200092, Peoples R China

Recommended Citation:
Guo, Xiao-hui,Lv, Xiao-feng,Han, Ping,et al. Efficacy and safety of glimepiride as initial treatment in Chinese patients with Type 2 diabetes mellitus[J]. CURRENT MEDICAL RESEARCH AND OPINION,2013,29(3):169-174.
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