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学科主题: 临床医学
题名:
Epidemiological study of severe cutaneous adverse drug reactions in a city district of China
作者: Li, L. -F.; Ma, C.
刊名: CLINICAL AND EXPERIMENTAL DERMATOLOGY
发表日期: 2006-09-01
DOI: 10.1111/j.1365-2230.2006.02185.x
卷: 31, 期:5, 页:642-647
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: TOXIC EPIDERMAL NECROLYSIS ; STEVENS-JOHNSON-SYNDROME ; ETIOLOGY
英文摘要:

An epidemiological study of severe cutaneous adverse drug reactions (SCADRs) in China has not been reported.

To estimate the incidence of SCADRs in a city district of China.

A retrospective study was performed in Peking University Third Hospital, the only hospital in Haidian district, Beijing with a dermatology ward. The medical records of inpatients with SCADRs from January 1994 to December 2002 were studied.

The prevalence rates for overall SCADRs, Stevens-Johnson syndrome (SJS), exfoliative dermatitis (ED), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) among hospitalized patients were 0.32, 0.15, 0.10, 0.04 and 0.07 per thousand, respectively. The risk of SCADRs from systemic drugs among hospitalized patients was 0.03/1000 (0.02/1000 for SJS, and 0.01/1000 for ED and DRESS). The reported incidence of SCADRs in Haidian district was not less than 1.8 per million person-years. The reported incidence of ED, SJS, TEN and DRESS in Haidian district was not less than 0.6, 0.8, 0.05 and 0.4 per million person-years, respectively. The most common underlying disorders were infection, pain-related diseases and epilepsy. Antibiotics were the most common offending drugs followed by anticonvulsants and traditional Chinese medicines (TCM).

These results confirm the relatively low incidence of SCADRs in China. Antibiotics, anticonvulsants and TCM are the most common causative drugs.

语种: 英语
WOS记录号: WOS:000239108700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62745
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Dermatol, Beijing 100083, Peoples R China

Recommended Citation:
Li, L. -F.,Ma, C.. Epidemiological study of severe cutaneous adverse drug reactions in a city district of China[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2006,31(5):642-647.
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