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Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats
Liu, Qing; Zhang, Min; Qin, Wang-Jun; Wang, Yan-Ting; Li, Yu-Ling; Jing, Li2; Li, Jun-Xu3; Lawrence, Andrew J.4,5; Liang, Jian-Hui1
关键词Morphine Septal nucleus Behavioral sensitization Conditioned place preference Antinociception Rat
刊名BRAIN RESEARCH
2012-05-15
DOI10.1016/j.brainres.2012.03.027
1454页:90-99
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]INCENTIVE-SENSITIZATION ; PLACE-PREFERENCE ; LATERAL SEPTUM ; FIMBRIA-FORNIX ; THETA-RHYTHM ; ADULT RATS ; LESIONS ; EXPRESSION ; AMPHETAMINE ; AMYGDALA
英文摘要

Behavioral sensitization to a single morphine injection is a unique model to study the neuroanatomical substrates of long-lasting behavioral plasticity associated with opioid reward and abuse. Earlier observations have demonstrated that septal nuclei are critically involved in the processes of reward, learning and memory. In the present study, we investigated the effects of septal nuclei lesions on behavioral sensitization to a single morphine injection, morphine induced conditioned place preference and antinociception in rats. Behavioral sensitization was established by a single injection of 3-30 mg/kg morphine in rats. Bilateral electrical lesions of septal nuclei were carried out 7 days before morphine pretreatment. Acute morphine injection induced hyperactivity in the non-surgery control, sham surgery and septal nuclei-lesioned rats. Seven days later, the challenge injection with 3 mg/kg morphine induced significant behavioral sensitization in rats with no surgery and sham surgery, but failed to induce behavioral sensitization in septal nuclei-lesioned rats. When the septal nuclei ablation was carried out after acute morphine pretreatment, the expression of behavioral sensitization was unaffected and not different among rats. In addition, septal nuclei lesions did not impact the rewarding and antinociceptive effects of 10 mg/kg morphine when the rats were tested in a conditioned place preference test and tail-flick test, respectively. Collectively, these results suggest that septal nuclei may be selectively involved in the initiation of behavioral sensitization to morphine, which is separable from the effects of morphine for exerting its rewarding and antinociceptive effects. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000304186200008
项目编号30870894 ; 2009CB522000 ; 2011BAK04B08
资助机构National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R&amp ; D Program in the 12th Five Year Plan of China ; National Health &amp ; Medical Research Council (Australia)
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62747
专题中国药物依赖性研究所
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 30070, Peoples R China
3.Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, Australia
4.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
5.Univ Melbourne, Florey Neurosci Inst, Parkville, Vic 3010, Australia
推荐引用方式
GB/T 7714
Liu, Qing,Zhang, Min,Qin, Wang-Jun,et al. Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats[J]. BRAIN RESEARCH,2012,1454:90-99.
APA Liu, Qing.,Zhang, Min.,Qin, Wang-Jun.,Wang, Yan-Ting.,Li, Yu-Ling.,...&Liang, Jian-Hui.(2012).Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats.BRAIN RESEARCH,1454,90-99.
MLA Liu, Qing,et al."Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats".BRAIN RESEARCH 1454(2012):90-99.
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