北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats
作者: Liu, Qing; Zhang, Min; Qin, Wang-Jun; Wang, Yan-Ting; Li, Yu-Ling; Jing, Li2; Li, Jun-Xu3; Lawrence, Andrew J.4,5; Liang, Jian-Hui1
关键词: Morphine ; Septal nucleus ; Behavioral sensitization ; Conditioned place preference ; Antinociception ; Rat
刊名: BRAIN RESEARCH
发表日期: 2012-05-15
DOI: 10.1016/j.brainres.2012.03.027
卷: 1454, 页:90-99
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: INCENTIVE-SENSITIZATION ; PLACE-PREFERENCE ; LATERAL SEPTUM ; FIMBRIA-FORNIX ; THETA-RHYTHM ; ADULT RATS ; LESIONS ; EXPRESSION ; AMPHETAMINE ; AMYGDALA
英文摘要:

Behavioral sensitization to a single morphine injection is a unique model to study the neuroanatomical substrates of long-lasting behavioral plasticity associated with opioid reward and abuse. Earlier observations have demonstrated that septal nuclei are critically involved in the processes of reward, learning and memory. In the present study, we investigated the effects of septal nuclei lesions on behavioral sensitization to a single morphine injection, morphine induced conditioned place preference and antinociception in rats. Behavioral sensitization was established by a single injection of 3-30 mg/kg morphine in rats. Bilateral electrical lesions of septal nuclei were carried out 7 days before morphine pretreatment. Acute morphine injection induced hyperactivity in the non-surgery control, sham surgery and septal nuclei-lesioned rats. Seven days later, the challenge injection with 3 mg/kg morphine induced significant behavioral sensitization in rats with no surgery and sham surgery, but failed to induce behavioral sensitization in septal nuclei-lesioned rats. When the septal nuclei ablation was carried out after acute morphine pretreatment, the expression of behavioral sensitization was unaffected and not different among rats. In addition, septal nuclei lesions did not impact the rewarding and antinociceptive effects of 10 mg/kg morphine when the rats were tested in a conditioned place preference test and tail-flick test, respectively. Collectively, these results suggest that septal nuclei may be selectively involved in the initiation of behavioral sensitization to morphine, which is separable from the effects of morphine for exerting its rewarding and antinociceptive effects. (c) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30870894 ; 2009CB522000 ; 2011BAK04B08
项目资助者: National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R&amp ; D Program in the 12th Five Year Plan of China ; National Health &amp ; Medical Research Council (Australia)
WOS记录号: WOS:000304186200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62747
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 30070, Peoples R China
3.Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, Australia
4.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
5.Univ Melbourne, Florey Neurosci Inst, Parkville, Vic 3010, Australia

Recommended Citation:
Liu, Qing,Zhang, Min,Qin, Wang-Jun,et al. Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats[J]. BRAIN RESEARCH,2012,1454:90-99.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Qing]'s Articles
[Zhang, Min]'s Articles
[Qin, Wang-Jun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Qing]‘s Articles
[Zhang, Min]‘s Articles
[Qin, Wang-Jun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace