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Size-fractioned particulate air pollution and cardiovascular emergency room visits in Beijing, China
Liu, Liqun1,2,3; Breitner, Susanne1,2; Schneider, Alexandra1; Cyrys, Josef1,4; Brueske, Irene5; Franck, Ulrich6; Schlink, Uwe6; Leitte, Arne Marian6; Herbarth, Olf6,7; Wiedensohler, Alfred8; Wehner, Birgit8; Pan, Xiaochuan3; Wichmann, H-Erich2,5; Peters, Annette1,9
关键词Accurately size-fractioned ambient particulate matter Cardiovascular emergency room visits Beijing Distributed lag non-linear model Particle number concentration Ultrafine particles
刊名ENVIRONMENTAL RESEARCH
2013-02-01
DOI10.1016/j.envres.2012.10.009
121页:52-63
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]HEART-RATE-VARIABILITY ; HOSPITAL ADMISSIONS ; TIME-SERIES ; COARSE PARTICLES ; EPIDEMIOLOGIC EVIDENCE ; NUMBER CONCENTRATIONS ; ULTRAFINE PARTICLES ; PERSONAL EXPOSURE ; DAILY MORTALITY ; MATTER
英文摘要

Background: Although short-term exposure to ambient particulate matter has increasingly been linked with cardiovascular diseases, it is not quite clear how physical characteristics of particles, such as particle size may be responsible for the association. This study aimed at investigating whether daily changes in number or mass concentrations of accurately size-segregated particles in the range of 3 nm-10 mu m are associated with daily cardiovascular emergency room visits in Beijing, China.

Methods: Cardiovascular emergency room visit counts, particle size distribution data, and meteorological data were collected from Mar. 2004 to Dec. 2006. Particle size distribution data was used to calculate particle number concentration in different size fractions, which were then converted to particle mass concentration assuming spherical particles. We applied a time-series analysis approach. We evaluated lagged associations between cardiovascular emergency room visits and particulate number and mass concentration using distributed lag non-linear models up to lag 10. We calculated percentage changes of cardiovascular emergency room visits, together with 95% confidence intervals (Cl), in association with an interquartile range (IQR, difference between the third and first quartile) increase of 11-day or 2-day moving average number or mass concentration of particulate matter within each size fraction, assuming linear effects. We put interaction terms between s`s\vl VE`s\vl Vaverage particulate concentration in the models to estimate the modification of the particle effects by season.

Results: We observed delayed associations between number concentration of ultrafine particles and cardiovascular emergency room visits, mainly from lag 4 to lag 10, mostly contributed by 10-30 nm and 30-50 nm particles. An IQR (9040 cm(-3)) increase in 11-day average number concentration of ultrafine particles was associated with a 7.2% (1.1-13.7%) increase in total, and a 7.9% (0.5-15.9%) increase in severe cardiovascular emergency room visits. The delayed effects of particulate mass concentration were small. Regarding immediate effects, 2-day average number concentration of Aitken mode (30-100 nm) particles had strongest effects. An IQR (2269 cm(-3)) increase in 2-day average number concentration of 30-50 nm particles led to a 2.4% (-1.5-6.5%) increase in total, and a 1.7% (-2.9-6.5%) increase in severe cardiovascular emergency room visits. The immediate effects of mass concentration came mainly from 1000-2500 nm particles. An IQR (11.7 mu g m(-3)) increase in 2-day average mass concentration of 1000-2500 nm particles led to an around 2.4% (0.4-4.4%) increase in total, and a 1.7% (-0.8-4.2%) increase in severe cardiovascular emergency room visits. The lagged effect curves of number and mass concentrations of 100-300 nm particles or 300-1000 nm particles were quite similar, indicating that using particulate number or mass concentrations seemed not to affect the cardiovascular effect (of particles within one size fraction). The effects of number concentration of ultrafine particles, sub-micrometer particles (3-1000 nm) and 10-30 nm particles were substantially higher in winter comparing with in summer.

Conclusions: Elevated concentration levels of sub-micrometer particles were associated with increased cardiovascular morbidity. Ultrafine particles showed delayed effects, while accumulation mode (100-1000 nm) particles showed immediate effects. Using number or mass concentrations did not affect the particle effects. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000315753700008
项目编号PE 1156/1-2 ; WI 621/16-1 ; 2008601213
资助机构German Research Foundation (DFG) ; State Scholarship Fund by the China Scholarship Council (CSC)
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62751
专题北京大学公共卫生学院
作者单位1.Univ Munich, IBE Chair Epidemiol, Munich, Germany
2.Univ Leipzig, D-04109 Leipzig, Germany
3.Leibniz Inst Tropospher Res IfT, Dept Phys, Leipzig, Germany
4.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany
5.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China
6.Univ Augsburg, Environm Sci Ctr WZU, D-86159 Augsburg, Germany
7.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany
8.UFZ Helmholtz Ctr Environm Res, Core Facil Studies, Leipzig, Germany
9.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Focus Network Nanoparticles & Hlth NanoHlth, Neuherberg, Germany
推荐引用方式
GB/T 7714
Liu, Liqun,Breitner, Susanne,Schneider, Alexandra,et al. Size-fractioned particulate air pollution and cardiovascular emergency room visits in Beijing, China[J]. ENVIRONMENTAL RESEARCH,2013,121:52-63.
APA Liu, Liqun.,Breitner, Susanne.,Schneider, Alexandra.,Cyrys, Josef.,Brueske, Irene.,...&Peters, Annette.(2013).Size-fractioned particulate air pollution and cardiovascular emergency room visits in Beijing, China.ENVIRONMENTAL RESEARCH,121,52-63.
MLA Liu, Liqun,et al."Size-fractioned particulate air pollution and cardiovascular emergency room visits in Beijing, China".ENVIRONMENTAL RESEARCH 121(2013):52-63.
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