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Serum Proteomic Analysis Reveals High Frequency of Haptoglobin Deficiency and Elevated Thyroxine Level in Heroin Addicts
Zhou, Bing-Ying1,2; Yan, Shi-Yan3; Shi, Wan-Lu1,2; Qu, Zhi3; Zhao, Xin1,2; Liu, Zhi-Min3; Pu, Xiao-Ping1,2
刊名PLOS ONE
2014-04-17
DOI10.1371/journal.pone.0095345
9期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Key Research Laboratory of Natural and Biomimetic Drugs Project, Peking University ; National "Twelfth FiveYear" Plan for Science &amp ; Technology Support ; National Key Research Laboratory of Natural and Biomimetic Drugs Project, Peking University ; National "Twelfth FiveYear" Plan for Science &amp ; Technology Support
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]COCAINE ADDICTION ; DIABETIC-PATIENTS ; PLASMA-PROTEOME ; ASSOCIATION ; POLYMORPHISMS ; DEPENDENCE ; GENE ; PLATELETS ; METHADONE ; ALBUMIN
英文摘要

Heroin addiction is a chronic, complex disease, often accompanied by other concomitant disorders, which may encumber effective prevention and treatment. To explore the differences in expression profiles of serum proteins in control and heroin addicts, we used two-dimensional electrophoresis coupled to MALDI-TOF/TOF, and identified 4 proteins of interest. Following validation of the increase in serum transthyretin, we assessed serum levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and observed a robust increase in T4 in heroin addicts compared to controls. In addition, we performed haptoglobin (Hp) phenotyping, and showed that the frequency of Hp0 (serum devoid of haptoglobin) was significantly higher in heroin addicts. Altogether, these findings indicated that: (1) thyroid hormone imbalance is present in heroin addicts; (2) anhaptoglobinemia (Hp0) might a risk factor or a deleterious effect of heroin abuse.

语种英语
所属项目编号2012 BAI01B07
资助者National Key Research Laboratory of Natural and Biomimetic Drugs Project, Peking University ; National "Twelfth FiveYear" Plan for Science &amp ; Technology Support ; National Key Research Laboratory of Natural and Biomimetic Drugs Project, Peking University ; National "Twelfth FiveYear" Plan for Science &amp ; Technology Support
WOS记录号WOS:000335309100107
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62753
专题北京大学药学院
作者单位1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100871, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Bing-Ying,Yan, Shi-Yan,Shi, Wan-Lu,et al. Serum Proteomic Analysis Reveals High Frequency of Haptoglobin Deficiency and Elevated Thyroxine Level in Heroin Addicts[J]. PLOS ONE,2014,9(4).
APA Zhou, Bing-Ying.,Yan, Shi-Yan.,Shi, Wan-Lu.,Qu, Zhi.,Zhao, Xin.,...&Pu, Xiao-Ping.(2014).Serum Proteomic Analysis Reveals High Frequency of Haptoglobin Deficiency and Elevated Thyroxine Level in Heroin Addicts.PLOS ONE,9(4).
MLA Zhou, Bing-Ying,et al."Serum Proteomic Analysis Reveals High Frequency of Haptoglobin Deficiency and Elevated Thyroxine Level in Heroin Addicts".PLOS ONE 9.4(2014).
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