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学科主题: 药学
题名:
Serum Proteomic Analysis Reveals High Frequency of Haptoglobin Deficiency and Elevated Thyroxine Level in Heroin Addicts
作者: Zhou, Bing-Ying1,2; Yan, Shi-Yan3; Shi, Wan-Lu1,2; Qu, Zhi3; Zhao, Xin1,2; Liu, Zhi-Min3; Pu, Xiao-Ping1,2
刊名: PLOS ONE
发表日期: 2014-04-17
DOI: 10.1371/journal.pone.0095345
卷: 9, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: COCAINE ADDICTION ; DIABETIC-PATIENTS ; PLASMA-PROTEOME ; ASSOCIATION ; POLYMORPHISMS ; DEPENDENCE ; GENE ; PLATELETS ; METHADONE ; ALBUMIN
英文摘要:

Heroin addiction is a chronic, complex disease, often accompanied by other concomitant disorders, which may encumber effective prevention and treatment. To explore the differences in expression profiles of serum proteins in control and heroin addicts, we used two-dimensional electrophoresis coupled to MALDI-TOF/TOF, and identified 4 proteins of interest. Following validation of the increase in serum transthyretin, we assessed serum levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and observed a robust increase in T4 in heroin addicts compared to controls. In addition, we performed haptoglobin (Hp) phenotyping, and showed that the frequency of Hp0 (serum devoid of haptoglobin) was significantly higher in heroin addicts. Altogether, these findings indicated that: (1) thyroid hormone imbalance is present in heroin addicts; (2) anhaptoglobinemia (Hp0) might a risk factor or a deleterious effect of heroin abuse.

语种: 英语
所属项目编号: 2012 BAI01B07
项目资助者: National Key Research Laboratory of Natural and Biomimetic Drugs Project, Peking University ; National "Twelfth FiveYear" Plan for Science &amp ; Technology Support
WOS记录号: WOS:000335309100107
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62753
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100871, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Bing-Ying,Yan, Shi-Yan,Shi, Wan-Lu,et al. Serum Proteomic Analysis Reveals High Frequency of Haptoglobin Deficiency and Elevated Thyroxine Level in Heroin Addicts[J]. PLOS ONE,2014,9(4).
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