IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes
Zhang, Xiang Yang1,2; Liang, Jun3; Chen, Da Chun2; Xiu, Mei Hong2; He, Jincai4; Cheng, Wei4; Wu, Zhiwei4; Yang, Fu De2; Haile, Colin N.1; Sun, Hongqiang2,5; Lu, Lin; Kosten, Therese A.1; Kosten, Thomas R.1,2
刊名PLOS ONE
2012-02-07
DOI10.1371/journal.pone.0030937
7期:2
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NICOTINE DEPENDENCE ; TOBACCO SMOKING ; TARDIVE-DYSKINESIA ; PARKINSONS-DISEASE ; MENTAL-ILLNESS ; SYMPTOMS ; INDIVIDUALS ; MEDICATION ; INPATIENTS ; DOPAMINE
英文摘要

The high prevalence of smoking in schizophrenia of European background may be related to smoking′s reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND) in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS), the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES), and the Abnormal Involuntary Movement Scale (AIMS). We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%), were more likely to be heavy smokers (61% vs 31%), and had lower smoking cessation rates (4% vs 9%) (all p<0.0001) than controls. Among the schizophrenia patients smoking prevalence increased with age, with the largest difference from controls in the age cohort of 55-75 years: 75% vs 46% (p<0.0001). Among the schizophrenia smokers 73% started to smoke before the onset of their illness by an average of 7.6 years. The patients with schizophrenia who were current smokers scored significantly lower on the PANSS negative symptom subscore (p<0.005), and on the SAES symptom scale (p<0.04; Bonferroni corrected p>0.05) than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

语种英语
WOS记录号WOS:000302180600017
项目编号U01-MH79639 ; K05-DA0454 ; P50-DA18827 ; 03T-459 ; 05T-726 ; VISN 16
资助机构United States National Institutes of Health ; Stanley Medical Research Institute ; Department of Veterans Affairs, Mental Illness Research, Education and Clinical Center (MIRECC)
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62763
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.First Affiliated Hosp, Wenzhou Med Coll, Wenzhou, Peoples R China
5.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Liang, Jun,Chen, Da Chun,et al. Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes[J]. PLOS ONE,2012,7(2).
APA Zhang, Xiang Yang.,Liang, Jun.,Chen, Da Chun.,Xiu, Mei Hong.,He, Jincai.,...&Kosten, Thomas R..(2012).Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes.PLOS ONE,7(2).
MLA Zhang, Xiang Yang,et al."Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes".PLOS ONE 7.2(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiang Yang]的文章
[Liang, Jun]的文章
[Chen, Da Chun]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiang Yang]的文章
[Liang, Jun]的文章
[Chen, Da Chun]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiang Yang]的文章
[Liang, Jun]的文章
[Chen, Da Chun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。