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学科主题: 精神卫生
题名:
Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes
作者: Zhang, Xiang Yang1,2; Liang, Jun3; Chen, Da Chun2; Xiu, Mei Hong2; He, Jincai4; Cheng, Wei4; Wu, Zhiwei4; Yang, Fu De2; Haile, Colin N.1; Sun, Hongqiang2,5; Lu, Lin; Kosten, Therese A.1; Kosten, Thomas R.1,2
刊名: PLOS ONE
发表日期: 2012-02-07
DOI: 10.1371/journal.pone.0030937
卷: 7, 期:2
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: NICOTINE DEPENDENCE ; TOBACCO SMOKING ; TARDIVE-DYSKINESIA ; PARKINSONS-DISEASE ; MENTAL-ILLNESS ; SYMPTOMS ; INDIVIDUALS ; MEDICATION ; INPATIENTS ; DOPAMINE
英文摘要:

The high prevalence of smoking in schizophrenia of European background may be related to smoking′s reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND) in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS), the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES), and the Abnormal Involuntary Movement Scale (AIMS). We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%), were more likely to be heavy smokers (61% vs 31%), and had lower smoking cessation rates (4% vs 9%) (all p<0.0001) than controls. Among the schizophrenia patients smoking prevalence increased with age, with the largest difference from controls in the age cohort of 55-75 years: 75% vs 46% (p<0.0001). Among the schizophrenia smokers 73% started to smoke before the onset of their illness by an average of 7.6 years. The patients with schizophrenia who were current smokers scored significantly lower on the PANSS negative symptom subscore (p<0.005), and on the SAES symptom scale (p<0.04; Bonferroni corrected p>0.05) than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

语种: 英语
所属项目编号: U01-MH79639 ; K05-DA0454 ; P50-DA18827 ; 03T-459 ; 05T-726 ; VISN 16
项目资助者: United States National Institutes of Health ; Stanley Medical Research Institute ; Department of Veterans Affairs, Mental Illness Research, Education and Clinical Center (MIRECC)
WOS记录号: WOS:000302180600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62763
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.First Affiliated Hosp, Wenzhou Med Coll, Wenzhou, Peoples R China
5.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Liang, Jun,Chen, Da Chun,et al. Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes[J]. PLOS ONE,2012,7(2).
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