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学科主题: 临床医学
题名:
Level of Kidney Function Correlates with Cognitive Decline
作者: Wang, Fang2; Zhang, LuXia2; Liu, LiSheng3; Wang, HaiYan1,2
关键词: Chronic kidney disease ; Cognitive function ; Albuminuria ; Kidney and cognitive function, Chinese population
刊名: AMERICAN JOURNAL OF NEPHROLOGY
发表日期: 2010
DOI: 10.1159/000315618
卷: 32, 期:2, 页:117-121
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: MINI-MENTAL-STATE ; HIGH BLOOD-PRESSURE ; OLDER-ADULTS ; CARDIOVASCULAR-DISEASE ; HEMODIALYSIS-PATIENTS ; IMPAIRMENT ; DEMENTIA ; POPULATION ; PREVALENCE ; CHINESE
英文摘要:

Background: Early stage chronic kidney disease has been related to cognitive decline recently, while the association between them has never been explored in a Chinese population. Methods: This prospective study included a 1,351 community-based Chinese population >40 years and with estimated glomerular filtration rate (eGFR) >30 ml/min/1.73 m(2). Kidney function was assessed by eGFR at baseline; cognitive function was evaluated by Mini-Mental State Examination (MMSE) both at baseline and 4 years later, and MMSE score decreased <= 2 was defined as cognitive decline using analysis of Reliable Change Indices. There were 1,243 participants (92.0%) with valid data of MMSE at the second visit. Results: Altogether there were 66 (5.3%) incident cognitive decline cases during 4 years of follow-up. After adjusting for potential confounders including urinary albumin-to-creatinine ratio, the odds ratio of developing cognitive decline was 1.35 (95% CI 0.69-2.65) among participants with eGFR 60-89 ml/min/1.73 m(2) and was 2.73 (95% CI 1.00-7.56) among participants with eGFR 30-59 ml/min/1.73 m(2), compared to those with eGFR >= 90 ml/min/1.73 m(2). Conclusion: Our prospective study suggests that kidney function is associated with a cognitive decline in a Chinese population and the relation is independent of urinary albumin excretion. Copyright (C) 2010 S. Karger AG, Basel

语种: 英语
项目资助者: China Health and Medical Development Foundation ; Beijing Municipal Science and Technology Commission ; International Society of Nephrology
WOS记录号: WOS:000280476600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62780
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Beijing Hypertens League Inst, Beijing, Peoples R China
2.Peking Univ First Hosp, Dept Med, Div Renal, Inst Nephrol, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Div Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Fang,Zhang, LuXia,Liu, LiSheng,et al. Level of Kidney Function Correlates with Cognitive Decline[J]. AMERICAN JOURNAL OF NEPHROLOGY,2010,32(2):117-121.
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