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Morphine withdrawal produces circadian rhythm alterations of clock genes in mesolimbic brain areas and peripheral blood mononuclear cells in rats
Li, Su-xia; Liu, Li-jing; Jiang, Wen-gao; Lu, Lin
关键词circadian rhythm clock genes morphine dependence spontaneous withdrawal
刊名JOURNAL OF NEUROCHEMISTRY
2009-06-01
DOI10.1111/j.1471-4159.2009.06086.x
109期:6页:1668-1679
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
资助者National Basic Research Program of China ; Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]NUCLEUS-ACCUMBENS CORE ; VENTRAL TEGMENTAL AREA ; SUPRACHIASMATIC NUCLEUS ; PREFRONTAL CORTEX ; COCAINE SENSITIZATION ; DIFFERENTIAL CHANGES ; LOCOMOTOR-ACTIVITY ; SEEKING BEHAVIOR ; PLACE PREFERENCE ; DOPAMINE SYSTEM
英文摘要

Previous studies have shown that clock genes are expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus, other brain regions, and peripheral tissues. Various peripheral oscillators can run independently of the SCN. However, no published studies have reported changes in the expression of clock genes in the rat central nervous system and peripheral blood mononuclear cells (PBMCs) after withdrawal from chronic morphine treatment. Rats were administered with morphine twice daily at progressively increasing doses for 7 days; spontaneous withdrawal signs were recorded 14 h after the last morphine administration. Then, brain and blood samples were collected at each of eight time points (every 3 h: ZT 9; ZT 12; ZT 15; ZT 18; ZT 21; ZT 0; ZT 3; ZT 6) to examine expression of rPER1 and rPER2 and rCLOCK. Rats presented obvious morphine withdrawal signs, such as teeth chattering, shaking, exploring, ptosis, and weight loss. In morphine-treated rats, rPER1 and rPER2 expression in the SCN, basolateral amygdala, and nucleus accumbens shell showed robust circadian rhythms that were essentially identical to those in control rats. However, robust circadian rhythm in rPER1 expression in the ventral tegmental area was completely phase-reversed in morphine-treated rats. A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats. These findings indicate that withdrawal from chronic morphine treatment resulted in desynchronization from the SCN rhythm, with blunting of rPER1 and rPER2 expression in reward-related neurocircuits and PBMCs.

语种英语
所属项目编号2007CB512302 ; 2009CB522004 ; 30670713 ; 30725016
资助者National Basic Research Program of China ; Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of China
WOS记录号WOS:000266268400010
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62781
专题中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Su-xia,Liu, Li-jing,Jiang, Wen-gao,et al. Morphine withdrawal produces circadian rhythm alterations of clock genes in mesolimbic brain areas and peripheral blood mononuclear cells in rats[J]. JOURNAL OF NEUROCHEMISTRY,2009,109(6):1668-1679.
APA Li, Su-xia,Liu, Li-jing,Jiang, Wen-gao,&Lu, Lin.(2009).Morphine withdrawal produces circadian rhythm alterations of clock genes in mesolimbic brain areas and peripheral blood mononuclear cells in rats.JOURNAL OF NEUROCHEMISTRY,109(6),1668-1679.
MLA Li, Su-xia,et al."Morphine withdrawal produces circadian rhythm alterations of clock genes in mesolimbic brain areas and peripheral blood mononuclear cells in rats".JOURNAL OF NEUROCHEMISTRY 109.6(2009):1668-1679.
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