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学科主题: 临床医学
题名:
Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis
作者: Chen, Yuqing6; Mahata, Manjula; Rao, Fangwen; Khandrika, Srikrishna; Courel, Maite; Fung, Maple M.; Zhang, Kuixing; Stridsberg, Mats4; Ziegler, Michael G.; Hamilton, Bruce A.; Lipkowitz, Michael S.5; Taupenot, Laurent; Nievergelt, Caroline; Mahata, Sushil K.1,3; O′ Connor, Daniel T.2,3,7
刊名: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2009-07-01
DOI: 10.1681/ASN.2008111148
卷: 20, 期:7, 页:1623-1632
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: REGION-SPECIFIC RADIOIMMUNOASSAYS ; ENDOTHELIAL-CELLS ; BLOOD-PRESSURE ; RECEPTOR ; FAILURE ; HYPERTENSION ; POLYMORPHISM ; SECRETION ; VASOSTATINS ; BIOGENESIS
英文摘要:

Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells. CHGA polymorphisms associate with an increased risk for ESRD, but whether altered CHGA-endothelium interactions may explain this association is unknown. Here, CHGA led to the release of endothelin-1 and Weibel-Palade body exocytosis in cultured human umbilical vein endothelial cells. In addition, CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta 1 from mesangial cells cocultured with glomerular endothelial cells. In humans, plasma CHGA correlated positively with endothelin-1 and negatively with GFR. GFR was highly heritable in twin pairs, and common promoter haplotypes of CHGA predicted GFR. In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function.

语种: 英语
所属项目编号: RR00827 ; MD000220
项目资助者: National Institutes of Health ; Department of Veterans Affairs ; International Society of Nephrology ; UCSD General Clinical Research Center ; UCSD Comprehensive Research Center in Health Disparities
WOS记录号: WOS:000267775400027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62784
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Mt Sinai Sch Med, Dept Med, New York, NY USA
2.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
3.Uppsala Univ, Dept Med Sci, Uppsala, Sweden
4.Vet Affairs San Diego Healthcare Syst, La Jolla, CA USA
5.Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
6.Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
7.Univ Calif San Diego, Ctr Human Genet & Genom, La Jolla, CA 92093 USA

Recommended Citation:
Chen, Yuqing,Mahata, Manjula,Rao, Fangwen,et al. Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2009,20(7):1623-1632.
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