IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis
Chen, Yuqing6; Mahata, Manjula; Rao, Fangwen; Khandrika, Srikrishna; Courel, Maite; Fung, Maple M.; Zhang, Kuixing; Stridsberg, Mats4; Ziegler, Michael G.; Hamilton, Bruce A.; Lipkowitz, Michael S.5; Taupenot, Laurent; Nievergelt, Caroline; Mahata, Sushil K.1,3; O′ Connor, Daniel T.2,3,7
刊名JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2009-07-01
DOI10.1681/ASN.2008111148
20期:7页:1623-1632
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]REGION-SPECIFIC RADIOIMMUNOASSAYS ; ENDOTHELIAL-CELLS ; BLOOD-PRESSURE ; RECEPTOR ; FAILURE ; HYPERTENSION ; POLYMORPHISM ; SECRETION ; VASOSTATINS ; BIOGENESIS
英文摘要

Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells. CHGA polymorphisms associate with an increased risk for ESRD, but whether altered CHGA-endothelium interactions may explain this association is unknown. Here, CHGA led to the release of endothelin-1 and Weibel-Palade body exocytosis in cultured human umbilical vein endothelial cells. In addition, CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta 1 from mesangial cells cocultured with glomerular endothelial cells. In humans, plasma CHGA correlated positively with endothelin-1 and negatively with GFR. GFR was highly heritable in twin pairs, and common promoter haplotypes of CHGA predicted GFR. In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function.

语种英语
WOS记录号WOS:000267775400027
项目编号RR00827 ; MD000220
资助机构National Institutes of Health ; Department of Veterans Affairs ; International Society of Nephrology ; UCSD General Clinical Research Center ; UCSD Comprehensive Research Center in Health Disparities
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62784
专题北京大学第一临床医学院_肾脏内科
作者单位1.Mt Sinai Sch Med, Dept Med, New York, NY USA
2.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
3.Uppsala Univ, Dept Med Sci, Uppsala, Sweden
4.Vet Affairs San Diego Healthcare Syst, La Jolla, CA USA
5.Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
6.Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
7.Univ Calif San Diego, Ctr Human Genet & Genom, La Jolla, CA 92093 USA
推荐引用方式
GB/T 7714
Chen, Yuqing,Mahata, Manjula,Rao, Fangwen,et al. Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2009,20(7):1623-1632.
APA Chen, Yuqing.,Mahata, Manjula.,Rao, Fangwen.,Khandrika, Srikrishna.,Courel, Maite.,...&Connor, Daniel T..(2009).Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,20(7),1623-1632.
MLA Chen, Yuqing,et al."Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis".JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20.7(2009):1623-1632.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Yuqing]的文章
[Mahata, Manjula]的文章
[Rao, Fangwen]的文章
百度学术
百度学术中相似的文章
[Chen, Yuqing]的文章
[Mahata, Manjula]的文章
[Rao, Fangwen]的文章
必应学术
必应学术中相似的文章
[Chen, Yuqing]的文章
[Mahata, Manjula]的文章
[Rao, Fangwen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。