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学科主题: 药学
题名:
Construction of the pharmacophore models of M-1 receptor agonists by distance comparison method
作者: Niu, Y; Pei, JF; Lu, W; Lei, XP
关键词: M-1 agonist ; distance comparison method ; pharmacophore model ; database searching
刊名: ACTA CHIMICA SINICA
发表日期: 2005-11-28
卷: 63, 期:22, 页:2021-2026
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: SELECTIVE MUSCARINIC AGONISTS
英文摘要:

Not knowing the 3D structure of muscarinic receptors, the pharmacophore models of M-1 agonists were constructed using 24 M-1 receptor agonists by distance comparison method, providing a reference for designing new M, agonists. A set of possible M-1 agonists to be novel in structure were selected by searching ACD and TCMDB databases with the attained model as a query.

语种: 中文
WOS记录号: WOS:000233700300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62787
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Niu, Y,Pei, JF,Lu, W,et al. Construction of the pharmacophore models of M-1 receptor agonists by distance comparison method[J]. ACTA CHIMICA SINICA,2005,63(22):2021-2026.
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