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学科主题: 药学
题名:
A comprehensive study of iRGD-modified liposomes with improved chemotherapeutic efficacy on B16 melanoma
作者: Dai, Wenbing1; Fan, Yuchen1; Zhang, Hua1; Wang, Xueqing1; Zhang, Qiang1; Wang, Xinglin2
关键词: B16 melanoma cells ; integrin receptors ; iRGD ; neuropilin-1 receptors ; tumor penetrating
刊名: DRUG DELIVERY
发表日期: 2015
DOI: 10.3109/10717544.2014.903580
卷: 22, 期:1, 页:10-20
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: STERICALLY STABILIZED LIPOSOMES ; IMPROVED ANTITUMOR EFFICACY ; DRUG-DELIVERY ; IN-VIVO ; INTRACELLULAR DELIVERY ; EXPRESSION PATTERNS ; INTEGRIN EXPRESSION ; GROWTH-FACTOR ; TUMOR ; DOXORUBICIN
英文摘要:

iRGD is a tumor tissue penetrating peptide due to its targeted binding of integrin and neuropilin-1 receptors. Whether iRGD carries the liposomes in a similar way as it penetrates the cancer drugs or conjugated drugs into tumor tissues and cells has not been fully defined. Here, iRGD-modified and doxorubicin-loaded sterically stabilized liposomes (iRGD-SSL-DOX) and passive liposomes (SSL-DOX) were prepared. A series of experiments were performed to evaluate the tissue penetration, cell penetration, tumor blood vessel damage and anti-tumor effect. The results of flow cytometry and confocal microscopy studies showed that iRGD-SSL-DOX with 5% DSPE-PEG2000-iRGD achieved higher cellular uptake level than that of SSL-DOX on B16 melanoma cells. iRGD-SSL-DOX also exhibited stronger cell growth inhibition in cytotoxicity experiments. The tumor penetrating effect of iRGD was further confirmed by imaging and cellular uptake studies in vivo, in which higher distribution of iRGD-modified liposomes in tumor tissue and tumor cells was observed. Moreover, iRGD-SSL-DOX displayed improved tumor growth inhibition and anti-angiogenesis with less systemic toxicity in an armpit B16 melanoma model. In conclusion, iRGD reserved its tumor-penetrating properties well when modified on the surface of liposomes at optimal density and iRGD-SSL-DOX would be a promising drug delivery system for active targeting tumor therapy.

语种: 英语
所属项目编号: 81130059 ; BMU20110263
项目资助者: National Science Foundation ; Innovation Team of the Ministry of Education of China
WOS记录号: WOS:000346975000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62788
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin, Peoples R China

Recommended Citation:
Dai, Wenbing,Fan, Yuchen,Zhang, Hua,et al. A comprehensive study of iRGD-modified liposomes with improved chemotherapeutic efficacy on B16 melanoma[J]. DRUG DELIVERY,2015,22(1):10-20.
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