北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 检验科  > 期刊论文
学科主题: 临床医学
题名:
In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis
作者: Fan, S. R.2; Liu, X. P.1
关键词: Vulvovaginal candidosis ; fluconazole ; nystatin ; susceptibility ; treatment
刊名: MYCOSES
发表日期: 2011-11-01
DOI: 10.1111/j.1439-0507.2010.01887.x
卷: 54, 期:6, 页:501-505
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology ; Mycology
研究领域[WOS]: Dermatology ; Mycology
关键词[WOS]: ANTIFUNGAL SUSCEPTIBILITY ; OROPHARYNGEAL CANDIDIASIS ; INTERPRETIVE BREAKPOINTS ; VAGINITIS ; ALBICANS ; ITRACONAZOLE ; RESISTANCE ; EPIDEMIOLOGY ; THERAPY ; YEASTS
英文摘要:

To correlate fluconazole and nystatin susceptibility with clinical outcome for complicated vulvovaginal candidosis (VVC), 287 Candida isolates were collected from 283 patients with complicated VVC. In vitro fluconazole and nystatin susceptibility was tested using E-test or commercial agar diffusion method. The patients were treated with fluconazole or nystatin. The fluconazole-resistant and -susceptible dose-dependent (SDD) rates of Candida species were 0.8% (1/132) and 5.3% (7/132) respectively. The mycological cure rate at days 7-14 and days 30-35 in fluconazole SDD isolates was lower than that in fluconazole-susceptible isolates (42.9% vs. 88.7% and 28.6% vs. 76.6%, P < 0.05). The mycological cure rate at days 7-14 and days 30-35 in VVC caused by Candida albicans and non-albicans Candida species was 85.6% (219/256) vs. 88.9% (24/27) and 79.3% (203/256) vs. 81.5% (22/27), P > 0.05. All C. albicans and non-albicans Candida species were susceptible to nystatin in vitro. The mycological cure rate of the patients treated with nystatin at days 7-14 and days 30-35 in VVC was 85.4% (129/151) and 83.4% (126/151) respectively. We conclude that fluconazole resistance was rare and both C. albicans and non-albicans Candida species were susceptible to nystatin in vitro. The decrease in fluconazole susceptibility or a low concentration of fluconazole in the vagina was probably related to fluconazole therapeutic failure.

语种: 英语
WOS记录号: WOS:000296243700043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62790
Appears in Collections:北京大学深圳医院_检验科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China

Recommended Citation:
Fan, S. R.,Liu, X. P.. In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis[J]. MYCOSES,2011,54(6):501-505.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Fan, S. R.]'s Articles
[Liu, X. P.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Fan, S. R.]‘s Articles
[Liu, X. P.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace