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In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis
Fan, S. R.2; Liu, X. P.1
关键词Vulvovaginal candidosis fluconazole nystatin susceptibility treatment
刊名MYCOSES
2011-11-01
DOI10.1111/j.1439-0507.2010.01887.x
54期:6页:501-505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology ; Mycology
研究领域[WOS]Dermatology ; Mycology
关键词[WOS]ANTIFUNGAL SUSCEPTIBILITY ; OROPHARYNGEAL CANDIDIASIS ; INTERPRETIVE BREAKPOINTS ; VAGINITIS ; ALBICANS ; ITRACONAZOLE ; RESISTANCE ; EPIDEMIOLOGY ; THERAPY ; YEASTS
英文摘要

To correlate fluconazole and nystatin susceptibility with clinical outcome for complicated vulvovaginal candidosis (VVC), 287 Candida isolates were collected from 283 patients with complicated VVC. In vitro fluconazole and nystatin susceptibility was tested using E-test or commercial agar diffusion method. The patients were treated with fluconazole or nystatin. The fluconazole-resistant and -susceptible dose-dependent (SDD) rates of Candida species were 0.8% (1/132) and 5.3% (7/132) respectively. The mycological cure rate at days 7-14 and days 30-35 in fluconazole SDD isolates was lower than that in fluconazole-susceptible isolates (42.9% vs. 88.7% and 28.6% vs. 76.6%, P < 0.05). The mycological cure rate at days 7-14 and days 30-35 in VVC caused by Candida albicans and non-albicans Candida species was 85.6% (219/256) vs. 88.9% (24/27) and 79.3% (203/256) vs. 81.5% (22/27), P > 0.05. All C. albicans and non-albicans Candida species were susceptible to nystatin in vitro. The mycological cure rate of the patients treated with nystatin at days 7-14 and days 30-35 in VVC was 85.4% (129/151) and 83.4% (126/151) respectively. We conclude that fluconazole resistance was rare and both C. albicans and non-albicans Candida species were susceptible to nystatin in vitro. The decrease in fluconazole susceptibility or a low concentration of fluconazole in the vagina was probably related to fluconazole therapeutic failure.

语种英语
WOS记录号WOS:000296243700043
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62790
专题北京大学深圳医院_检验科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
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GB/T 7714
Fan, S. R.,Liu, X. P.. In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis[J]. MYCOSES,2011,54(6):501-505.
APA Fan, S. R.,&Liu, X. P..(2011).In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis.MYCOSES,54(6),501-505.
MLA Fan, S. R.,et al."In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis".MYCOSES 54.6(2011):501-505.
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