北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension
作者: Shi, Y; Du, JB; Guo, ZL; Zeng, CM; Tang, CS
关键词: carbon monoxide/metab ; nitric oxide/metab ; hypoxia ; hypertension ; pulmonary/epidemiol
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2003
卷: 48, 期:1, 页:86-90
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENE-EXPRESSION ; VASCULAR ENDOTHELIUM ; HEME OXYGENASE-1 ; GROWTH-FACTORS ; VASOCONSTRICTORS
英文摘要:

The aim of the study was to investigate the interaction between nitric oxygenase (NOS)/ nitric oxide (NO) and heme oxygenase (HO)/ carbon monoxide (CO) system in the pathogenesis of hypoxic pulmonary hypertension. On a rat model of hypoxic pulmonary hypertension, the pulmonary artery pressure was measured, and NO formation and expression of NOS in pulmonary tissues were examined after treatment with ZnPP-IX, an HO-1 inhibitor. The pulmonary artery pressure, CO formation and expression of HO-1 in pulmonary tissues were examined after treatment with L-NAME, a NOS inhibitor. We found that pulmonary hypertension developed after 2-week hypoxia, while the concentration of NO in the pulmonary tissue homogenates and the expression of NOS in intrapulmonary artery endothelial cells decreased markedly. ZnPP-IX worsened pulmonary hypertension of hypoxic rats. However, it increased endogenous production of NO and the expression of NOS obviously. The concentration of CO in the pulmonary tissue homogenates and the expression of HO-1 in intraptulmonary artery smooth muscle cells increased markedly with hypoxic pulmonary hypertension. L-NAME worsened pulmonary hypertension of hypoxic rats, but inhibited CO formation and HO-1 expression (P < 0.01). The results or this study suggested that endogenous NOS/NO and HO/CO systems might interact with each other and therefore play an important regulating role in hypoxic pulmonary hypertension.

语种: 英语
WOS记录号: WOS:000180522700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62791
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Shi, Y,Du, JB,Guo, ZL,et al. Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension[J]. CHINESE SCIENCE BULLETIN,2003,48(1):86-90.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Y]'s Articles
[Du, JB]'s Articles
[Guo, ZL]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Y]‘s Articles
[Du, JB]‘s Articles
[Guo, ZL]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace