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学科主题: 临床医学
题名:
Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function
作者: Zhu, Tian Gang3; Patel, Chinmay1,2,4; Martin, Seth1,2; Quan, Xin3,4; Wu, Ying1,2; Burke, James F.1,2,5; Chernick, Michael4; Kowey, Peter R.1,2,4,5; Yan, Gan-Xin1,2,4,5,6
关键词: T Wave ; Ventricular repolarization ; Ventricular relaxation ; Diastolic function
刊名: EUROPEAN HEART JOURNAL
发表日期: 2009-02-01
DOI: 10.1093/eurheartj/ehn585
卷: 30, 期:3, 页:372-380
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CARDIAC RESYNCHRONIZATION THERAPY ; LONG-QT SYNDROME ; HEART-FAILURE ; T-WAVE ; SYSTOLIC FUNCTION ; DISPERSION ; DYSFUNCTION ; ECG ; HETEROGENEITY ; INTERVALS
英文摘要:

We investigated the role of ventricular repolarization sequence in ventricular diastolic function.

Arterially perfused canine left ventricular wedge preparation with simultaneous recording of action potentials and isometric contractile force was used to establish the relationship between ventricular repolarization and relaxation sequences. An isolated rabbit working heart model was used to investigate role of ventricular repolarization sequence in ventricular diastolic function. Under controlled conditions, similar to transmural dispersion of repolarization (TDR), there existed a time difference between initiation of epicardial and endocardial relaxation (TR(Epi-Endo), 47.4 +/- 13.9 ms) with epicardium relaxing earlier. There was a strong correlation between TDR and TR(Epi-Endo) (r(2) = 0.99, n = 5) and the interventions that changed transmural repolarization sequence led to parallel changes in transmural relaxation sequence. In isolated rabbit working hearts, reversal of the transmural repolarization sequence that manifested as negative T wave was associated with a significant increase in isovolumic relaxation time (from 49.2 +/- 19.1 to 76.4 +/- 12.1 ms, n = 5, P = 0.001).

There is a strong correlation between transmural repolarization and relaxation sequences. A positive T wave that denotes transmural repolarization sequence from epicardium to endocardium is essential for normal diastolic function of ventricle and the reversal of such sequence is associated with ventricular diastolic dysfunction.

语种: 英语
所属项目编号: 30670846
项目资助者: National Nature Science Foundation of China ; W. W. Smith Charitable Trust ; Sharpe-Strumia Research Foundation ; Albert M. Greenfield Foundation
WOS记录号: WOS:000263163500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62799
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA
2.Lankenau Med Ctr, Wynnewood, PA 19096 USA
3.Lankenau Inst Med Res, Wynnewood, PA USA
4.Peking Univ, Peoples Hosp, Div Cardiol, Beijing 100871, Peoples R China
5.Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA
6.Xi An Jiao Tong Univ, Hosp 1, Xian 710049, Peoples R China

Recommended Citation:
Zhu, Tian Gang,Patel, Chinmay,Martin, Seth,et al. Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function[J]. EUROPEAN HEART JOURNAL,2009,30(3):372-380.
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