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学科主题临床医学
Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function
Zhu, Tian Gang3; Patel, Chinmay1,2,4; Martin, Seth1,2; Quan, Xin3,4; Wu, Ying1,2; Burke, James F.1,2,5; Chernick, Michael4; Kowey, Peter R.1,2,4,5; Yan, Gan-Xin1,2,4,5,6
关键词T Wave Ventricular repolarization Ventricular relaxation Diastolic function
刊名EUROPEAN HEART JOURNAL
2009-02-01
DOI10.1093/eurheartj/ehn585
30期:3页:372-380
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Nature Science Foundation of China ; W. W. Smith Charitable Trust ; Sharpe-Strumia Research Foundation ; Albert M. Greenfield Foundation ; National Nature Science Foundation of China ; W. W. Smith Charitable Trust ; Sharpe-Strumia Research Foundation ; Albert M. Greenfield Foundation
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CARDIAC RESYNCHRONIZATION THERAPY ; LONG-QT SYNDROME ; HEART-FAILURE ; T-WAVE ; SYSTOLIC FUNCTION ; DISPERSION ; DYSFUNCTION ; ECG ; HETEROGENEITY ; INTERVALS
英文摘要

We investigated the role of ventricular repolarization sequence in ventricular diastolic function.

Arterially perfused canine left ventricular wedge preparation with simultaneous recording of action potentials and isometric contractile force was used to establish the relationship between ventricular repolarization and relaxation sequences. An isolated rabbit working heart model was used to investigate role of ventricular repolarization sequence in ventricular diastolic function. Under controlled conditions, similar to transmural dispersion of repolarization (TDR), there existed a time difference between initiation of epicardial and endocardial relaxation (TR(Epi-Endo), 47.4 +/- 13.9 ms) with epicardium relaxing earlier. There was a strong correlation between TDR and TR(Epi-Endo) (r(2) = 0.99, n = 5) and the interventions that changed transmural repolarization sequence led to parallel changes in transmural relaxation sequence. In isolated rabbit working hearts, reversal of the transmural repolarization sequence that manifested as negative T wave was associated with a significant increase in isovolumic relaxation time (from 49.2 +/- 19.1 to 76.4 +/- 12.1 ms, n = 5, P = 0.001).

There is a strong correlation between transmural repolarization and relaxation sequences. A positive T wave that denotes transmural repolarization sequence from epicardium to endocardium is essential for normal diastolic function of ventricle and the reversal of such sequence is associated with ventricular diastolic dysfunction.

语种英语
所属项目编号30670846
资助者National Nature Science Foundation of China ; W. W. Smith Charitable Trust ; Sharpe-Strumia Research Foundation ; Albert M. Greenfield Foundation ; National Nature Science Foundation of China ; W. W. Smith Charitable Trust ; Sharpe-Strumia Research Foundation ; Albert M. Greenfield Foundation
WOS记录号WOS:000263163500016
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62799
Collection北京大学第二临床医学院_心血管内科
作者单位1.Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA
2.Lankenau Med Ctr, Wynnewood, PA 19096 USA
3.Lankenau Inst Med Res, Wynnewood, PA USA
4.Peking Univ, Peoples Hosp, Div Cardiol, Beijing 100871, Peoples R China
5.Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA
6.Xi An Jiao Tong Univ, Hosp 1, Xian 710049, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Tian Gang,Patel, Chinmay,Martin, Seth,et al. Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function[J]. EUROPEAN HEART JOURNAL,2009,30(3):372-380.
APA Zhu, Tian Gang.,Patel, Chinmay.,Martin, Seth.,Quan, Xin.,Wu, Ying.,...&Yan, Gan-Xin.(2009).Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function.EUROPEAN HEART JOURNAL,30(3),372-380.
MLA Zhu, Tian Gang,et al."Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function".EUROPEAN HEART JOURNAL 30.3(2009):372-380.
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