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学科主题: 基础医学
题名:
Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: A clinicopathological study of 6 cases
作者: Kazakov, Dmitry V.1; Magro, Gaetano2; Kutzner, Heinz3; Spagnolo, Dominic V.4; Yang, Yu5; Zaspa, Oksana6; Mukensnabl, Petr1; Michal, Michal1,7
关键词: cutaneous adnexal tumors ; spiradenoma ; spiradenocylindroma ; myoepithelial cells ; adenomyoepithelioma ; clear cell
刊名: AMERICAN JOURNAL OF DERMATOPATHOLOGY
发表日期: 2008-10-01
卷: 30, 期:5, 页:436-441
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: CLEAR-CELL TRICHOBLASTOMA ; BROOKE-SPIEGLER-SYNDROME ; SWEAT GLAND TUMORS ; ECCRINE SPIRADENOMA ; MYOEPITHELIAL DIFFERENTIATION ; NEVUS SEBACEUS ; CARCINOMA ; BENIGN ; SKIN ; NEOPLASM
英文摘要:

We report 5 cases of spiradenoma and 1 case of spiradenocylindroma, which, in addition to areas of conventional growth, manifested an adenomatous component. This consisted of compactly situated, well-developed glands having small round lumens lined by inner pale to eosinophilic cells and surrounded by an outer well-formed peripheral layer of myoepithelial cells, which reacted with a variety of myoepithelial cell markers. In 1 case, apocrine secretion was evident in the glandular part of the lesion. In 4 of the 6 cases, the adenomatous component was a minor but significant portion of the tumors, but in 2 cases it was extensive, comprising approximately 20% of the tumor area. In 1 of these 2 cases, the luminal epithelium showed atypia including rare, atypical mitotic figures. In addition, there were foci of glands showing myoepithelial cell loss. As this alteration was limited and fairly well circumscribed within the tumor bulk, we regard it as an "atypical adenomatous component," but we cannot exclude the possibility that this may represent an incipient apocrine carcinoma, despite uneventful follow-up. Three cases also manifested clear cell areas. Immunohistochemical studies demonstrated that myoepithelial proliferation and overgrowth accounted for the clear cell change in some of the lesions.

语种: 英语
WOS记录号: WOS:000259325000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62804
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.PathWest Lab Med WA, Div Tissue Pathol, Nedlands, WA, Australia
2.NN Blochin Russian Canc Res Ctr, Dept Pathol, Moscow, Russia
3.Biopt Lab, Plzen, Czech Republic
4.Univ Catania, GF Ingrassias Dept, Catania, Italy
5.Dermatohistopathol Gemeinschaftspraxis, Friedrichshafen, Germany
6.Charles Univ Prague, Med Fac Hosp, Sikls Dept Pathol, Plzen 30460, Czech Republic
7.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Kazakov, Dmitry V.,Magro, Gaetano,Kutzner, Heinz,et al. Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: A clinicopathological study of 6 cases[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY,2008,30(5):436-441.
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