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学科主题基础医学
Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: A clinicopathological study of 6 cases
Kazakov, Dmitry V.1; Magro, Gaetano2; Kutzner, Heinz3; Spagnolo, Dominic V.4; Yang, Yu5; Zaspa, Oksana6; Mukensnabl, Petr1; Michal, Michal1,7
关键词cutaneous adnexal tumors spiradenoma spiradenocylindroma myoepithelial cells adenomyoepithelioma clear cell
刊名AMERICAN JOURNAL OF DERMATOPATHOLOGY
2008-10-01
30期:5页:436-441
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]CLEAR-CELL TRICHOBLASTOMA ; BROOKE-SPIEGLER-SYNDROME ; SWEAT GLAND TUMORS ; ECCRINE SPIRADENOMA ; MYOEPITHELIAL DIFFERENTIATION ; NEVUS SEBACEUS ; CARCINOMA ; BENIGN ; SKIN ; NEOPLASM
英文摘要

We report 5 cases of spiradenoma and 1 case of spiradenocylindroma, which, in addition to areas of conventional growth, manifested an adenomatous component. This consisted of compactly situated, well-developed glands having small round lumens lined by inner pale to eosinophilic cells and surrounded by an outer well-formed peripheral layer of myoepithelial cells, which reacted with a variety of myoepithelial cell markers. In 1 case, apocrine secretion was evident in the glandular part of the lesion. In 4 of the 6 cases, the adenomatous component was a minor but significant portion of the tumors, but in 2 cases it was extensive, comprising approximately 20% of the tumor area. In 1 of these 2 cases, the luminal epithelium showed atypia including rare, atypical mitotic figures. In addition, there were foci of glands showing myoepithelial cell loss. As this alteration was limited and fairly well circumscribed within the tumor bulk, we regard it as an "atypical adenomatous component," but we cannot exclude the possibility that this may represent an incipient apocrine carcinoma, despite uneventful follow-up. Three cases also manifested clear cell areas. Immunohistochemical studies demonstrated that myoepithelial proliferation and overgrowth accounted for the clear cell change in some of the lesions.

语种英语
WOS记录号WOS:000259325000004
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62804
专题北京大学基础医学院_病理学系
作者单位1.PathWest Lab Med WA, Div Tissue Pathol, Nedlands, WA, Australia
2.NN Blochin Russian Canc Res Ctr, Dept Pathol, Moscow, Russia
3.Biopt Lab, Plzen, Czech Republic
4.Univ Catania, GF Ingrassias Dept, Catania, Italy
5.Dermatohistopathol Gemeinschaftspraxis, Friedrichshafen, Germany
6.Charles Univ Prague, Med Fac Hosp, Sikls Dept Pathol, Plzen 30460, Czech Republic
7.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Kazakov, Dmitry V.,Magro, Gaetano,Kutzner, Heinz,et al. Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: A clinicopathological study of 6 cases[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY,2008,30(5):436-441.
APA Kazakov, Dmitry V..,Magro, Gaetano.,Kutzner, Heinz.,Spagnolo, Dominic V..,Yang, Yu.,...&Michal, Michal.(2008).Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: A clinicopathological study of 6 cases.AMERICAN JOURNAL OF DERMATOPATHOLOGY,30(5),436-441.
MLA Kazakov, Dmitry V.,et al."Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: A clinicopathological study of 6 cases".AMERICAN JOURNAL OF DERMATOPATHOLOGY 30.5(2008):436-441.
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