IR@PKUHSC  > 北京大学药学院
学科主题药学
The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study
Liu, MJ; Li, JX; Guo, HZ; Lee, KM; Qin, L; Chan, KM
关键词immobilization lipid peroxidation erythrocyte membrane fluidity oxidative stress verbascoside
刊名LIFE SCIENCES
2003-07-04
DOI10.1016/S0024-3205(03)00354-0
73期:7页:883-892
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]SKELETAL-MUSCLE ; OXIDATIVE STRESS ; PHENYLPROPANOID GLYCOSIDES ; SPIN-LABEL ; VITAMIN-E ; ATROPHY ; MALONYLDIALDEHYDE ; ABNORMALITIES ; HYPERTENSION ; PEDICULARIS
英文摘要

We studied the changes in the level of plasma lipid peroxidation indicated by malondialdehyde (MDA) level and erythrocyte membrane fluidity expressed by the value of order parameter (S) during single hindlimb immobilization of 21 days using thiobarbituric acid - reactive substances method and spin label electron spin resonance method, respectively. The impacts of verbascoside that has been proved its antioxidative activity on the measured parameters were examined. I I New Zealand white rabbits were immobilized and divided into two groups. The rabbits in the verbascoside group were administrated with 0.8 mg/kg of verbascoside twice a day orally throughout the immobilization. The rabbits in the placebo group were treated with normal saline. In placebo group, the results showed that the level of MDA significantly increased on day 3, peaked on day 7, and was still significantly higher on day 14 of immobilization, compared with the value measured before immobilization. The value of S reached the highest on day 7 and subsequently lowered but still higher on day 14 than those measured before immobilization. Compared with placebo group, there were lower MDA level (P < 0.05, 0.001, and 0.05 for days 3, 7, and 14, respectively) and higher erythrocyte membrane fluidity (P < 0.05, 0.001, and 0.001 for days 3, 7, and 14, respectively) in verbascoside group. The data indicated that immobilization caused temporal changes of increase in plasma lipid peroxidation and decrease in erythrocyte membrane fluidity. Verbascoside might have the effects to moderate oxidative stress and erythrocyte membrane fluidity during immobilization. (C) 2003 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000183718400005
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62807
专题北京大学药学院
作者单位1.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Dept Sport Sci & Phys Educ, Shatin, Hong Kong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognost Biotechnol, Beijing 100083, Peoples R China
4.Chinese Univ Hong Kong, Lee Hysan Clin Res Lab, Shatin, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Liu, MJ,Li, JX,Guo, HZ,et al. The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study[J]. LIFE SCIENCES,2003,73(7):883-892.
APA Liu, MJ,Li, JX,Guo, HZ,Lee, KM,Qin, L,&Chan, KM.(2003).The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study.LIFE SCIENCES,73(7),883-892.
MLA Liu, MJ,et al."The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study".LIFE SCIENCES 73.7(2003):883-892.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, MJ]的文章
[Li, JX]的文章
[Guo, HZ]的文章
百度学术
百度学术中相似的文章
[Liu, MJ]的文章
[Li, JX]的文章
[Guo, HZ]的文章
必应学术
必应学术中相似的文章
[Liu, MJ]的文章
[Li, JX]的文章
[Guo, HZ]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。