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学科主题: 药学
题名:
The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study
作者: Liu, MJ; Li, JX; Guo, HZ; Lee, KM; Qin, L; Chan, KM
关键词: immobilization ; lipid peroxidation ; erythrocyte membrane fluidity ; oxidative stress ; verbascoside
刊名: LIFE SCIENCES
发表日期: 2003-07-04
DOI: 10.1016/S0024-3205(03)00354-0
卷: 73, 期:7, 页:883-892
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: SKELETAL-MUSCLE ; OXIDATIVE STRESS ; PHENYLPROPANOID GLYCOSIDES ; SPIN-LABEL ; VITAMIN-E ; ATROPHY ; MALONYLDIALDEHYDE ; ABNORMALITIES ; HYPERTENSION ; PEDICULARIS
英文摘要:

We studied the changes in the level of plasma lipid peroxidation indicated by malondialdehyde (MDA) level and erythrocyte membrane fluidity expressed by the value of order parameter (S) during single hindlimb immobilization of 21 days using thiobarbituric acid - reactive substances method and spin label electron spin resonance method, respectively. The impacts of verbascoside that has been proved its antioxidative activity on the measured parameters were examined. I I New Zealand white rabbits were immobilized and divided into two groups. The rabbits in the verbascoside group were administrated with 0.8 mg/kg of verbascoside twice a day orally throughout the immobilization. The rabbits in the placebo group were treated with normal saline. In placebo group, the results showed that the level of MDA significantly increased on day 3, peaked on day 7, and was still significantly higher on day 14 of immobilization, compared with the value measured before immobilization. The value of S reached the highest on day 7 and subsequently lowered but still higher on day 14 than those measured before immobilization. Compared with placebo group, there were lower MDA level (P < 0.05, 0.001, and 0.05 for days 3, 7, and 14, respectively) and higher erythrocyte membrane fluidity (P < 0.05, 0.001, and 0.001 for days 3, 7, and 14, respectively) in verbascoside group. The data indicated that immobilization caused temporal changes of increase in plasma lipid peroxidation and decrease in erythrocyte membrane fluidity. Verbascoside might have the effects to moderate oxidative stress and erythrocyte membrane fluidity during immobilization. (C) 2003 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000183718400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62807
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Dept Sport Sci & Phys Educ, Shatin, Hong Kong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognost Biotechnol, Beijing 100083, Peoples R China
4.Chinese Univ Hong Kong, Lee Hysan Clin Res Lab, Shatin, Hong Kong, Peoples R China

Recommended Citation:
Liu, MJ,Li, JX,Guo, HZ,et al. The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study[J]. LIFE SCIENCES,2003,73(7):883-892.
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