IR@PKUHSC  > 北京大学第二临床医学院  > 麻醉科
学科主题临床医学
Combined Vagal Stimulation and Limb Remote Ischemic Perconditioning Enhances Cardioprotection via an Anti-inflammatory Pathway
Wang, Qiang1; Liu, Gao-Pu2,3; Xue, Fu-Shan2,3; Wang, Shi-Yu2,3; Cui, Xin-Long2,3; Li, Rui-Ping2,3; Yang, Gui-Zhen2,3; Sun, Chao2,3; Liao, Xu2,3
关键词ischemia-reperfusion injury vagal stimulation limb remote ischemic perconditioning combined perconditioning inflammation cardioprotection
刊名INFLAMMATION
2015-10-01
DOI10.1007/s10753-015-0152-y
38期:5页:1748-1760
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]MYOCARDIAL ISCHEMIA/REPERFUSION INJURY ; REPERFUSION-INJURY ; INFLAMMATORY RESPONSE ; POSTCONDITIONING PROTECTS ; DEPENDENT MECHANISM ; VAGUS NERVE ; INFARCTION ; RATS ; HEART ; MELANOCORTINS
英文摘要

Various combined interventions to acquire enhanced cardioprotection are prevalent focuses of current research. This randomized experiment assessed whether combined vagal stimulation perconditioning (VSPerC) and limb remote ischemic perconditioning (LRIPerC) improved cardioprotection compared to the use of either treatment alone in an in vivo rat model of myocardial ischemia/reperfusion injury. A total of 100 male Sprague Dawley rats were randomly allocated into five groups: sham group, ischemia/reperfusion (IR) group, VSPerC group, LRIPerC group, and combined VSPerC and LRIPerC (COMPerC) group. Serum enzymatic markers, inflammatory cytokines, myocardial inflammatory cytokines, and infarct size were assessed. Infarct size decreased significantly in the COMPerC group compared to the VSPerC and LRIPerC groups. Serum intercellular adhesion molecule 1 (ICAM-1) level at 120 min of reperfusion, myocardial interleukin-1 (IL-1), ICAM-1, and tumor necrosis factor alpha (TNF-alpha) levels in the ischemic region decreased significantly in the COMPerC group compared to the VSPerC group, but myocardial IL-10 levels in the nonischemic region increased markedly in the COMPerC group. Serum TNF-alpha levels at 30, 60, and 120 min of reperfusion; serum IL-1, IL-6, ICAM-1, and high mobility group box-1 protein (HMGB-1) levels at 120 min of reperfusion; and myocardial IL-1, IL-6, ICAM-1, and TNF-alpha levels in the ischemic region decreased significantly in the COMPerC group compared to the LRIPerC group. However, myocardial IL-10 levels in both ischemic and nonischemic regions were evidently higher in the COMPerC group. This study concludes that combined VSPerC and LRIPerC enhances cardioprotection compared to either treatment alone. This result is likely attributable to a more potent regulation of inflammation.

语种英语
WOS记录号WOS:000360847200002
项目编号81170128
资助机构National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62808
专题北京大学第二临床医学院_麻醉科
作者单位1.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100871, Peoples R China
2.ChineseAcademy Med Sci, Plast Surg Hosp, Dept Anesthesiol, Beijing 100144, Peoples R China
3.Peking Union Med Coll, Beijing 100144, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qiang,Liu, Gao-Pu,Xue, Fu-Shan,et al. Combined Vagal Stimulation and Limb Remote Ischemic Perconditioning Enhances Cardioprotection via an Anti-inflammatory Pathway[J]. INFLAMMATION,2015,38(5):1748-1760.
APA Wang, Qiang.,Liu, Gao-Pu.,Xue, Fu-Shan.,Wang, Shi-Yu.,Cui, Xin-Long.,...&Liao, Xu.(2015).Combined Vagal Stimulation and Limb Remote Ischemic Perconditioning Enhances Cardioprotection via an Anti-inflammatory Pathway.INFLAMMATION,38(5),1748-1760.
MLA Wang, Qiang,et al."Combined Vagal Stimulation and Limb Remote Ischemic Perconditioning Enhances Cardioprotection via an Anti-inflammatory Pathway".INFLAMMATION 38.5(2015):1748-1760.
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