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学科主题: 临床医学
题名:
Combined Vagal Stimulation and Limb Remote Ischemic Perconditioning Enhances Cardioprotection via an Anti-inflammatory Pathway
作者: Wang, Qiang1; Liu, Gao-Pu2,3; Xue, Fu-Shan2,3; Wang, Shi-Yu2,3; Cui, Xin-Long2,3; Li, Rui-Ping2,3; Yang, Gui-Zhen2,3; Sun, Chao2,3; Liao, Xu2,3
关键词: ischemia-reperfusion injury ; vagal stimulation ; limb remote ischemic perconditioning ; combined perconditioning ; inflammation ; cardioprotection
刊名: INFLAMMATION
发表日期: 2015-10-01
DOI: 10.1007/s10753-015-0152-y
卷: 38, 期:5, 页:1748-1760
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: MYOCARDIAL ISCHEMIA/REPERFUSION INJURY ; REPERFUSION-INJURY ; INFLAMMATORY RESPONSE ; POSTCONDITIONING PROTECTS ; DEPENDENT MECHANISM ; VAGUS NERVE ; INFARCTION ; RATS ; HEART ; MELANOCORTINS
英文摘要:

Various combined interventions to acquire enhanced cardioprotection are prevalent focuses of current research. This randomized experiment assessed whether combined vagal stimulation perconditioning (VSPerC) and limb remote ischemic perconditioning (LRIPerC) improved cardioprotection compared to the use of either treatment alone in an in vivo rat model of myocardial ischemia/reperfusion injury. A total of 100 male Sprague Dawley rats were randomly allocated into five groups: sham group, ischemia/reperfusion (IR) group, VSPerC group, LRIPerC group, and combined VSPerC and LRIPerC (COMPerC) group. Serum enzymatic markers, inflammatory cytokines, myocardial inflammatory cytokines, and infarct size were assessed. Infarct size decreased significantly in the COMPerC group compared to the VSPerC and LRIPerC groups. Serum intercellular adhesion molecule 1 (ICAM-1) level at 120 min of reperfusion, myocardial interleukin-1 (IL-1), ICAM-1, and tumor necrosis factor alpha (TNF-alpha) levels in the ischemic region decreased significantly in the COMPerC group compared to the VSPerC group, but myocardial IL-10 levels in the nonischemic region increased markedly in the COMPerC group. Serum TNF-alpha levels at 30, 60, and 120 min of reperfusion; serum IL-1, IL-6, ICAM-1, and high mobility group box-1 protein (HMGB-1) levels at 120 min of reperfusion; and myocardial IL-1, IL-6, ICAM-1, and TNF-alpha levels in the ischemic region decreased significantly in the COMPerC group compared to the LRIPerC group. However, myocardial IL-10 levels in both ischemic and nonischemic regions were evidently higher in the COMPerC group. This study concludes that combined VSPerC and LRIPerC enhances cardioprotection compared to either treatment alone. This result is likely attributable to a more potent regulation of inflammation.

语种: 英语
所属项目编号: 81170128
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000360847200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62808
Appears in Collections:北京大学第二临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100871, Peoples R China
2.ChineseAcademy Med Sci, Plast Surg Hosp, Dept Anesthesiol, Beijing 100144, Peoples R China
3.Peking Union Med Coll, Beijing 100144, Peoples R China

Recommended Citation:
Wang, Qiang,Liu, Gao-Pu,Xue, Fu-Shan,et al. Combined Vagal Stimulation and Limb Remote Ischemic Perconditioning Enhances Cardioprotection via an Anti-inflammatory Pathway[J]. INFLAMMATION,2015,38(5):1748-1760.
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