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学科主题口腔医学
Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus
Ai, Tingting1; Chen, Feng2; Zhou, Shaonan1; Zhang, Jieni1; Zheng, Hui1; Zhou, Yanheng1; Hu, Wei1; Liu, Xiaofei3; Li, Li4; Lin, Jiuxiang1
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/586309
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]OXIDATIVE STRESS ; INSULIN-RESISTANCE ; MASS-SPECTROMETRY ; CLUSTERIN/APOLIPOPROTEIN-J ; INTERNATIONAL ASSOCIATION ; BIOMARKER DISCOVERY ; NORMAL-PREGNANCY ; FREE-RADICALS ; PLASMA ; CANCER
英文摘要

Gestational diabetes mellitus (GDM) is a frequent medical condition during pregnancy. Early diagnosis and treatment of GDM are crucial for both the mother and the baby. In the present study, we aimed to identify specific biomarkers to assist in the early detection of GDM and give some clues to the possible causes of GDM by comparing serum peptide profile differences between GDM patients and healthy controls. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used in combination with weak cation exchange magnetic bead (WCX-MB). Levels of four peptides (4418.9, 2219.7, 2211.5, and 1533.4 Da) were significantly different. Interestingly, three of them (4418.9, 2211.5, and 1533.4 Da) were identified when GDM patients with two degrees of glucose intolerance were compared. Additionally, peptides 2211.5 and 1533.4 Da showed a decreasing trend as glucose intolerance increased, while peptide 4418.9 Da exhibited the reverse tendency. In conclusion, our study provides novel insights into the altered serum peptide profile of GDM patients. The specific candidate biomarkers may contribute to the development of GDM.

语种英语
WOS记录号WOS:000355436200001
项目编号2012YQ180117 ; 2014AA020900 ; PKUSS20110301
资助机构National Key Scientific Instrument and Equipment Development Projects ; Peking University School of Stomatology
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62809
专题北京大学口腔医学院_牙周科
北京大学第二临床医学院_血液科
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Sch Stomatol, Cent Lab, Beijing 100081, Peoples R China
2.Beijing Bioyong Technol Inc, Beijing 100085, Peoples R China
3.Peking Univ, Sch Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
4.Beijing Haidian Maternal & Child Hlth Hosp, Clin Lab, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Ai, Tingting,Chen, Feng,Zhou, Shaonan,et al. Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Ai, Tingting.,Chen, Feng.,Zhou, Shaonan.,Zhang, Jieni.,Zheng, Hui.,...&Lin, Jiuxiang.(2015).Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus.BIOMED RESEARCH INTERNATIONAL.
MLA Ai, Tingting,et al."Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus".BIOMED RESEARCH INTERNATIONAL (2015).
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