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学科主题: 口腔医学
题名:
Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus
作者: Ai, Tingting1; Chen, Feng2; Zhou, Shaonan1; Zhang, Jieni1; Zheng, Hui1; Zhou, Yanheng1; Hu, Wei1; Liu, Xiaofei3; Li, Li4; Lin, Jiuxiang1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/586309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: OXIDATIVE STRESS ; INSULIN-RESISTANCE ; MASS-SPECTROMETRY ; CLUSTERIN/APOLIPOPROTEIN-J ; INTERNATIONAL ASSOCIATION ; BIOMARKER DISCOVERY ; NORMAL-PREGNANCY ; FREE-RADICALS ; PLASMA ; CANCER
英文摘要:

Gestational diabetes mellitus (GDM) is a frequent medical condition during pregnancy. Early diagnosis and treatment of GDM are crucial for both the mother and the baby. In the present study, we aimed to identify specific biomarkers to assist in the early detection of GDM and give some clues to the possible causes of GDM by comparing serum peptide profile differences between GDM patients and healthy controls. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used in combination with weak cation exchange magnetic bead (WCX-MB). Levels of four peptides (4418.9, 2219.7, 2211.5, and 1533.4 Da) were significantly different. Interestingly, three of them (4418.9, 2211.5, and 1533.4 Da) were identified when GDM patients with two degrees of glucose intolerance were compared. Additionally, peptides 2211.5 and 1533.4 Da showed a decreasing trend as glucose intolerance increased, while peptide 4418.9 Da exhibited the reverse tendency. In conclusion, our study provides novel insights into the altered serum peptide profile of GDM patients. The specific candidate biomarkers may contribute to the development of GDM.

语种: 英语
所属项目编号: 2012YQ180117 ; 2014AA020900 ; PKUSS20110301
项目资助者: National Key Scientific Instrument and Equipment Development Projects ; Peking University School of Stomatology
WOS记录号: WOS:000355436200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62809
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Cent Lab, Beijing 100081, Peoples R China
2.Beijing Bioyong Technol Inc, Beijing 100085, Peoples R China
3.Peking Univ, Sch Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
4.Beijing Haidian Maternal & Child Hlth Hosp, Clin Lab, Beijing 100080, Peoples R China

Recommended Citation:
Ai, Tingting,Chen, Feng,Zhou, Shaonan,et al. Magnetic Bead-Based Serum Peptidome Profiling in Patients with Gestational Diabetes Mellitus[J]. BIOMED RESEARCH INTERNATIONAL,2015.
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