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学科主题: 药物依赖
题名:
Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice
作者: Jing, Li1,2; Zhang, Min4; Li, Jun-Xu2; Huang, Ping5; Liu, Qing3; Li, Yu-Ling3; Liang, Hui3; Liang, Jian-Hui3
关键词: Methamphetamine ; Behavioral sensitization ; Single-dose injection ; Repeated-dose injection
刊名: NEUROSCIENCE LETTERS
发表日期: 2014-02-07
DOI: 10.1016/j.neulet.2013.12.024
卷: 560, 页:103-106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NEUROCHEMICAL SENSITIZATION ; MORPHINE EXPOSURE ; AMPHETAMINE ; COCAINE ; EXPRESSION ; RATS ; PRETREATMENT ; INHIBITORS ; ADDICTION
英文摘要:

Repeated exposure to drugs of abuse produces a persistent behavioral sensitization to stimulants, which is often used to study drug-associated behavioral plasticity. Interestingly, even a single exposure to some drugs of abuse is sufficient to elicit long-lasting behavioral sensitization. However, few studies have directly compared the magnitude of sensitization between single versus repeated drug treatments. This study examined the magnitude and duration of single methamphetamine (METH) injection-induced behavioral sensitization and compared it to the more typical repeated drug injection-induced sensitization in mice. Different groups of mice were injected with METH (0.5, 1.0, 2.0 mg/kg, i.p.) only once or daily for 7 consecutive days. A challenge dose of METH (1.0 mg/kg, i.p.) was tested 7 days later. The time-course of a single METH injection-induced behavioral sensitization was assessed where METH (2.0 mg/kg, i.p.) was injected and a challenge dose of METH (1.0 mg/kg, i.p.) was tested after different drug-free periods. Single METH injection produced similar magnitude of behavioral sensitization as compared to repeated injection. Such a sensitized locomotor response peaked 8 days after METH injection and lasted for at least 21 days. This long lasting behavioral alteration induced by single METH injection suggests the value of future studies to explore the underlying neural mechanisms, particularly in comparison to those underlying repeated METH-induced sensitization. Published by Elsevier Ireland Ltd.

语种: 英语
所属项目编号: 30870894 ; 2009CB522000 ; 2011BAKO4B08 ; 2009ZDYJHLJT003 ; R01DA034806 ; R21DA033426 ; 81373390
项目资助者: National Nature Science Foundation of China ; National Basic Research Program of China ; National Key Technology R&amp ; D Program of China ; Key Research Items of Ministry of Public Security ; National Institute on Drug Abuse of the National Institutes of Health ; National Natural Science Foundation of China
WOS记录号: WOS:000331022700021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62815
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China
2.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Tsinghua Univ, Sch Med, Beijing 100083, Peoples R China
5.Guangzhou Univ Chinese Med, Coll Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China

Recommended Citation:
Jing, Li,Zhang, Min,Li, Jun-Xu,et al. Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice[J]. NEUROSCIENCE LETTERS,2014,560:103-106.
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