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IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population
作者: Tu, Hua-kang1,3; Pan, Kai-feng1; Zhang, Yang1; Li, Wen-qing1; Zhang, Lian1; Ma, Jun-ling1; Li, Ji-you2; You, Wei-cheng1
刊名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
发表日期: 2010-04-01
DOI: 10.1158/1055-9965.EPI-09-1174
卷: 19, 期:4, 页:1089-1097
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: PROSTATE-CANCER RISK ; HELICOBACTER-PYLORI INFECTION ; OXYGEN METABOLITE PRODUCTION ; MNSOD GENE POLYMORPHISM ; OXIDATIVE DNA-DAMAGE ; PRECANCEROUS LESIONS ; FACTORIAL TRIAL ; STOMACH-CANCER ; BREAST-CANCER ; ASSOCIATION
英文摘要:

Background: Manganese superoxide dismutase is the primary antioxidant enzyme in the mitochondria and is involved in carcinogenesis. To investigate the association between MnSOD Val16Ala polymorphism and risk of advanced gastric lesions, and its effects on chemoprevention, a population-based study was conducted in Linqu, a high-risk area of gastric cancer in China.

Methods: Genotypes were determined by PCR-RFLP analysis in 3,355 subjects with the baseline histopathologic diagnosis in 1994, and 2,758 of these subjects received subsequent three interventions including vitamin supplementation for 7.3 years. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression model.

Results: We found an increased risk of dysplasia in subjects with the Val/Ala+ Ala/Ala genotype (OR, 1.31; 95% CI, 1.02-1.68) compared with the Val/Val genotype. Stratified analysis indicated that a significantly elevated risk of intestinal metaplasia (OR, 3.40; 95% CI, 2.64-4.38) or dysplasia (OR, 4.01; 95% CI, 2.79-5.74) was found in subjects carrying the Val/Ala+ Ala/Ala genotype and Helicobacter pylori infection, and an interaction between this genotype and a high serum H. pylori IgG titer (> 2.94) on the risk of dysplasia was observed (Pinteraction = 0.01). Furthermore, an elevated chance for regression of gastric lesions was observed in subjects with the Val/Ala+ Ala/Ala genotype and high IgG titer in an intervention trial with vitamin supplementation (OR, 2.45; 95% CI, 1.37-4.38).

Conclusions: These findings suggest that Val16Ala polymorphism may play an important role in development of advanced gastric lesions and modify the effect of vitamin supplementation on the evolution of gastric lesions. Impact: Val16Ala polymorphism is related to gastric cancer development. Cancer Epidemiol Biomarkers Prev; 19(4); 1089-97. (C) 2010 AACR.

语种: 英语
WOS记录号: WOS:000278484400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62821
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: 1.Peking Univ, Dept Canc Epidemiol, Sch Oncol, Minist Educ,Beijing Canc Hosp & Inst,Key Lab Carc, Beijing 100142, Peoples R China
2.Peking Univ, Dept Pathol, Sch Oncol, Minist Educ,Beijing Canc Hosp & Inst,Key Lab Carc, Beijing 100142, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100142, Peoples R China

Recommended Citation:
Tu, Hua-kang,Pan, Kai-feng,Zhang, Yang,et al. Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2010,19(4):1089-1097.
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