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Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing
Sun, Xiang1,2,3; Allison, Carrie2,3; Matthews, Fiona E.4; Zhang, Zhixiang5; Auyeung, Bonnie2,3,6; Baron-Cohen, Simon2,3; Brayne, Carol1
关键词autism prevalence screening diagnosis prevalence CAST China
刊名AUTISM RESEARCH
2015-06-01
DOI10.1002/aur.1441
8期:3页:250-260
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Behavioral Sciences ; Psychology, Developmental
资助者Waterloo Foundation ; Peking University First Hospital ; Cambridge Institute of Public Health ; Autism Research Trust ; Cambridge Commonwealth Trust ; Clare Hall of the University of Cambridge ; Great Britain-China Educational Trust ; International Development Fund-Cambridge-CUHK Collaboration on Autism Research in Hong Kong and China ; Medical Research Council UK ; Wellcome Trust ; NIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation Trust ; MRC UK ; Waterloo Foundation ; Peking University First Hospital ; Cambridge Institute of Public Health ; Autism Research Trust ; Cambridge Commonwealth Trust ; Clare Hall of the University of Cambridge ; Great Britain-China Educational Trust ; International Development Fund-Cambridge-CUHK Collaboration on Autism Research in Hong Kong and China ; Medical Research Council UK ; Wellcome Trust ; NIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation Trust ; MRC UK
研究领域[WOS]Behavioral Sciences ; Psychology
关键词[WOS]CAST CHILDHOOD ASPERGER ; MAINLAND CHINA ; DISEASE VERIFICATION ; HONG-KONG ; CHILDREN ; IDENTIFICATION ; QUESTIONNAIRE ; DISORDERS ; CHECKLIST ; ACCURACY
英文摘要

Previous studies reported that the prevalence of Autism Spectrum Conditions (ASC) in mainland China is much lower than estimates from developed countries (around 1%). The aim of the study is to apply current screening and standardized diagnostic instruments to a Chinese population to establish a prevalence estimate of ASC in an undiagnosed population in mainland China. We followed the design development used previously in the UK published in 2009 by Baron-Cohen and colleagues. The Mandarin Childhood Autism Spectrum Test (CAST) was validated by screening primary school pupils (n = 737 children age 6-10 years old) in Beijing and by conducting diagnostic assessments using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised. The prevalence estimate was generated after adjusting and imputing for missing values using the inverse probability weighting. Response was high (97%). Using the UK cutoff (>= 15), CAST performance has 84% sensitivity and 96% specificity (95% confidence interval [CI]: 46, 98, and 96, 97, respectively). Six out of 103 children, not previously diagnosed, were found to the meet diagnostic criteria (8.5 after adjustment, 95% CI: 1.6, 15.4). The preliminary prevalence in an undiagnosed primary school population in mainland China was 119 per 10,000 (95% CI: 53, 265). The utility of CAST is acceptable as a screening instrument for ASC in large epidemiological studies in China. Using a comparable method, the preliminary prevalence estimate of ASC in mainland China is similar to that of those from developed countries.(C) 2015 The Authors. Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research

语种英语
资助者Waterloo Foundation ; Peking University First Hospital ; Cambridge Institute of Public Health ; Autism Research Trust ; Cambridge Commonwealth Trust ; Clare Hall of the University of Cambridge ; Great Britain-China Educational Trust ; International Development Fund-Cambridge-CUHK Collaboration on Autism Research in Hong Kong and China ; Medical Research Council UK ; Wellcome Trust ; NIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation Trust ; MRC UK ; Waterloo Foundation ; Peking University First Hospital ; Cambridge Institute of Public Health ; Autism Research Trust ; Cambridge Commonwealth Trust ; Clare Hall of the University of Cambridge ; Great Britain-China Educational Trust ; International Development Fund-Cambridge-CUHK Collaboration on Autism Research in Hong Kong and China ; Medical Research Council UK ; Wellcome Trust ; NIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation Trust ; MRC UK
WOS记录号WOS:000360446600002
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62822
Collection北京大学第一临床医学院_儿科
作者单位1.Univ Cambridge, Cambridge Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England
2.Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England
3.Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England
4.Cambridge Inst Publ Hlth, MRC Biostat Unit, Cambridge, England
5.Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland
6.Peking Univ, Dept Pediat, Hosp 1, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Sun, Xiang,Allison, Carrie,Matthews, Fiona E.,et al. Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing[J]. AUTISM RESEARCH,2015,8(3):250-260.
APA Sun, Xiang.,Allison, Carrie.,Matthews, Fiona E..,Zhang, Zhixiang.,Auyeung, Bonnie.,...&Brayne, Carol.(2015).Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing.AUTISM RESEARCH,8(3),250-260.
MLA Sun, Xiang,et al."Exploring the Underdiagnosis and Prevalence of Autism Spectrum Conditions in Beijing".AUTISM RESEARCH 8.3(2015):250-260.
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