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学科主题: 临床医学
题名:
Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China
作者: Wang, Yingmei1; Xue, Fengxia1,2; Broaddus, Russell R.3; Tao, Xia2,4; Xie, Su-su3; Zhu, Yanbin1
关键词: Endometrial carcinoma ; Lynch syndrome ; Clinicopathological characteristic
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2009-05-01
DOI: 10.1111/IGC.0b013e3181a12fb9
卷: 19, 期:4, 页:651-656
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: NONPOLYPOSIS COLORECTAL-CANCER ; DNA-MISMATCH-REPAIR ; MICROSATELLITE INSTABILITY ; GYNECOLOGIC CANCER ; HNPCC ; WOMEN ; RISK ; TUMORS ; DEFECTS
英文摘要:

Objective: To Study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China.

Methods: Twenty-seven patients who fulfilled Amsterdam criteria 11 were classified as having Lynch syndrome-associated endometrial carcinoma (group A), and 33 1 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (group B).

Results: There were 81 malignancies in 27 families with Lynch syndrome-associated endometrial carcinoma, including colorectal cancer (24.7%), endometrial carcinoma (21.0%), and liver (12.3%), stomach (9.9%), lung (6.2%), and breast (6.2%) cancers. Mean age at the time of diagnosis was 49.7 years in group A and 56.3 years in group B (P = 0.004). Second primary cancers occurred in 33.3% of patients in group A and 5.1% in group B (P = 0.000). The most common second primary cancers were colorectal cancer (44%) and ovarian cancer (22%). The percentage of obese patients was higher in group A (P=0.013). There was no difference between the 2 groups in incidence of diabetes mellitus or hypertension or in histological type and International Federation of Gynecology and Obstetrics stage. The 5-year survival rates for groups A and B were 96.2% and 79.6%, respectively. Prognosis for group A was better than for group B (P = 0.045).

Conclusions: Some clinicopathological features of Lynch syndrome-associated endometrial carcinoma, Such as early onset and multiple primary carcinomas are similar in the Chinese and American/European Populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. Well-differentiated grade and good prognosis imply better biobehavior of Lynch syndrome-associated endometrial carcinoma In the Chinese Population.

语种: 英语
WOS记录号: WOS:000266976800026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62834
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Tianjin Med Univ, Dept Obstet & Gynecol, Gen Hosp, Tianjin 300052, Peoples R China
2.Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA
3.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
4.Peking Univ, Dept Obstet & Gynecol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Yingmei,Xue, Fengxia,Broaddus, Russell R.,et al. Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2009,19(4):651-656.
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