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Fluoxetine for the prophylaxis of poststroke depression in patients with stroke: a meta-analysis
Yi, Z. M.1,2; Liu, F.1; Zhai, S. D.1
刊名INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
2010-08-01
DOI10.1111/j.1742-1241.2010.02437.x
64期:9页:1310-1317
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]FUNCTIONAL RECOVERY
英文摘要

P>Background:

Depression may affect patients′ recovery and even their survival rate after stroke, but it is often overlooked or inadequately managed; data regarding the prophylactic efficacy and safety of fluoxetine are inconsistent in this setting.

Objective:

The objective of the study is to systematically assess the prophylactic efficacy and safety of fluoxetine for poststroke depression in patients with stroke.

Methods:

We searched electronic databases up to December 2009 for studies evaluating the prophylactic efficacy of fluoxetine in patients with stroke. The pooled odds ratio (OR), weighted mean difference (WMD), incremental efficiency and 95% confidence intervals (95% CI) were calculated.

Results:

We collected and evaluated a total of 385 patients identified from six trials. Meta-analysis demonstrated that fluoxetine reduced the incidence of poststroke depression (PSD) (OR = 0.25, 95% CI 0.11 to 0.56), helped recovery in neurological function (WMD = -4.72, 95% CI -8.31 to -1.13) and improved independence in activities of daily living (WMD = -8.04, 95% CI -13.40 to -2.68); fluoxetine is relatively safe in spite of the adverse events (OR = 0.88, 95% CI 0.31 to 2.49, p = 0.82). However, fluoxetine groups and control groups did not differ in change of scores for depression (WMD = -3.97, 95% CI -9.85 to 1.90, p = 0.19).

Conclusions:

Fluoxetine was beneficial for the prophylaxis of poststroke depression in patients with stroke but not in reducing symptom severity of PSD.

语种英语
WOS记录号WOS:000279901200023
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62838
专题北京大学第三临床医学院_药剂科
作者单位1.Peking Univ Third Hosp, Dept Pharm, Beijing, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yi, Z. M.,Liu, F.,Zhai, S. D.. Fluoxetine for the prophylaxis of poststroke depression in patients with stroke: a meta-analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2010,64(9):1310-1317.
APA Yi, Z. M.,Liu, F.,&Zhai, S. D..(2010).Fluoxetine for the prophylaxis of poststroke depression in patients with stroke: a meta-analysis.INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,64(9),1310-1317.
MLA Yi, Z. M.,et al."Fluoxetine for the prophylaxis of poststroke depression in patients with stroke: a meta-analysis".INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 64.9(2010):1310-1317.
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