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学科主题: 临床医学
题名:
Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration
作者: Kou, Yu-hui; Zhang, Pei-xun; Wang, Yan-hua; Chen, Bo; Han, Na; Xue, Feng; Zhang, Hong-bo; Yin, Xiao-feng; Jiang, Bao-guo
关键词: nerve regeneration ; peripheral nerve ; rhesus monkey ; muscular branches of pronator teres ; ulnar nerve ; multiple amplification ; small gap ; sleeve bridging ; NSFC grants ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015
DOI: 10.4103/1673-5374.150706
卷: 10, 期:1, 页:53-59
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: BRACHIAL-PLEXUS INJURIES ; MESENCHYMAL STEM-CELLS ; MEDIAN NERVE ; SMALL-GAP ; PERIPHERAL-NERVES ; REPAIR ; RECONSTRUCTION ; NANOTECHNOLOGY ; TRANSFERS ; DEFECTS
英文摘要:

Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regeneration using small gap sleeve bridging of small donor nerves to repair large receptor nerves in rodents. The present study sought to observe multiple amplification of myelinated nerve fiber regeneration in the primate peripheral nerve. Rhesus monkey models of distal ulnar nerve defects were established and repaired using muscular branches of the right forearm pronator teres. Proximal muscular branches of the pronator teres were sutured into the distal ulnar nerve using the small gap sleeve bridging method. At 6 months after suture, two-finger flexion and mild wrist flexion were restored in the ulnar-sided injured limbs of rhesus monkey. Neurophysiological examination showed that motor nerve conduction velocity reached 22.63 +/- 6.34 m/s on the affected side of rhesus monkey. Osmium tetroxide staining demonstrated that the number of myelinated nerve fibers was 1,657 +/- 652 in the branches of pronator teres of donor, and 2,661 +/- 843 in the repaired ulnar nerve. The rate of multiple amplification of regenerating myelinated nerve fibers was 1.61. These data showed that when muscular branches of the pronator teres were used to repair ulnar nerve in primates, effective regeneration was observed in regenerating nerve fibers, and functions of the injured ulnar nerve were restored to a certain extent. Moreover, multiple amplification was subsequently detected in ulnar nerve axons.

语种: 英语
所属项目编号: 2014CB542200 ; 31271284 ; 81171146 ; 31100860 ; IRT1201 ; 7142164
项目资助者: National Program on Key Basic Research Project of China (973 Program) ; National Natural Science Foundation of China ; Program for Innovative Research Team in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
WOS记录号: WOS:000350098100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62843
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China

Recommended Citation:
Kou, Yu-hui,Zhang, Pei-xun,Wang, Yan-hua,et al. Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration[J]. NEURAL REGENERATION RESEARCH,2015,10(1):53-59.
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