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学科主题临床医学
Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration
Kou, Yu-hui; Zhang, Pei-xun; Wang, Yan-hua; Chen, Bo; Han, Na; Xue, Feng; Zhang, Hong-bo; Yin, Xiao-feng; Jiang, Bao-guo
关键词nerve regeneration peripheral nerve rhesus monkey muscular branches of pronator teres ulnar nerve multiple amplification small gap sleeve bridging NSFC grants neural regeneration
刊名NEURAL REGENERATION RESEARCH
2015
DOI10.4103/1673-5374.150706
10期:1页:53-59
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]BRACHIAL-PLEXUS INJURIES ; MESENCHYMAL STEM-CELLS ; MEDIAN NERVE ; SMALL-GAP ; PERIPHERAL-NERVES ; REPAIR ; RECONSTRUCTION ; NANOTECHNOLOGY ; TRANSFERS ; DEFECTS
英文摘要

Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regeneration using small gap sleeve bridging of small donor nerves to repair large receptor nerves in rodents. The present study sought to observe multiple amplification of myelinated nerve fiber regeneration in the primate peripheral nerve. Rhesus monkey models of distal ulnar nerve defects were established and repaired using muscular branches of the right forearm pronator teres. Proximal muscular branches of the pronator teres were sutured into the distal ulnar nerve using the small gap sleeve bridging method. At 6 months after suture, two-finger flexion and mild wrist flexion were restored in the ulnar-sided injured limbs of rhesus monkey. Neurophysiological examination showed that motor nerve conduction velocity reached 22.63 +/- 6.34 m/s on the affected side of rhesus monkey. Osmium tetroxide staining demonstrated that the number of myelinated nerve fibers was 1,657 +/- 652 in the branches of pronator teres of donor, and 2,661 +/- 843 in the repaired ulnar nerve. The rate of multiple amplification of regenerating myelinated nerve fibers was 1.61. These data showed that when muscular branches of the pronator teres were used to repair ulnar nerve in primates, effective regeneration was observed in regenerating nerve fibers, and functions of the injured ulnar nerve were restored to a certain extent. Moreover, multiple amplification was subsequently detected in ulnar nerve axons.

语种英语
WOS记录号WOS:000350098100017
项目编号2014CB542200 ; 31271284 ; 81171146 ; 31100860 ; IRT1201 ; 7142164
资助机构National Program on Key Basic Research Project of China (973 Program) ; National Natural Science Foundation of China ; Program for Innovative Research Team in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62843
专题北京大学第二临床医学院
北京大学第一临床医学院_临床药理研究所
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
北京大学口腔医学院_口腔种植科
作者单位Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
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GB/T 7714
Kou, Yu-hui,Zhang, Pei-xun,Wang, Yan-hua,et al. Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration[J]. NEURAL REGENERATION RESEARCH,2015,10(1):53-59.
APA Kou, Yu-hui.,Zhang, Pei-xun.,Wang, Yan-hua.,Chen, Bo.,Han, Na.,...&Jiang, Bao-guo.(2015).Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration.NEURAL REGENERATION RESEARCH,10(1),53-59.
MLA Kou, Yu-hui,et al."Sleeve bridging of the rhesus monkey ulnar nerve with muscular branches of the pronator teres: multiple amplification of axonal regeneration".NEURAL REGENERATION RESEARCH 10.1(2015):53-59.
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