IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Peroxisome proliferator - activate receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery disease
Yu, Jie; Jin, Nan; Wang, Guang; Zhang, Fuchun; Mao, Jieming; Wang, Xian
刊名METABOLISM-CLINICAL AND EXPERIMENTAL
2007-10-01
DOI10.1016/j.metabot.2007.05.011
56期:10页:1396-1401
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]GENE-EXPRESSION ; PPAR-GAMMA ; IN-VITRO ; PIOGLITAZONE ; ROSIGLITAZONE ; INFLAMMATION ; VESSELS ; GROWTH ; PART
英文摘要

Arterial stiffness is an independent risk factor for cardiovascular events in diabetic patients, and it can be assessed by measuring pulse wave velocity (PWV). We investigated the degree of arterial stiffness in diabetic patients with coronary artery disease (CAD) and the effect of the proliferator-activated receptor gamma (PPAR-gamma) agonist rosiglitazone on arterial stiffness in the potential mechanism of anti-arteriosclerosis in patients with type 2 diabetes mellitus and CAD. The 123 participants were divided into 3 groups: healthy controls (n = 36), diabetic patients (n = 41), and diabetic patients with CAD (n = 46). Forty-six diabetic patients with CAD were randomly divided into 2 groups: untreated diabetic patients with CAD and diabetic patients with CAD treated with 4 mg/d of rosiglitazone (n = 25) for 12 weeks. Pulse wave velocity was measured before treatment and at 12-week follow-up. Baseline PWV was significantly higher in patients with diabetes, diabetes and CAD. and diabetes and CAD with treatment as compared with the healthy control group (1633 +/- 37.3, 1669 +/- 53.8, 1615 +/- 44.4, and 1360 +/- 39.9 cm/s. respectively. P <.001). Pulse wave velocity in the rosiglitazone-treated group was significantly reduced, from 1615 +/- 44.4 to 1525 +/- 43.1 cm/s. after 12-week treatment, Furthermore, PWV was significantly decreased in the rosiglitazone-treated group compared with untreated group after 12 weeks (1525 +/- 43.1 and 1670 +/- 41.3 cm/s, respectively). Pulse wave velocity in the untreated group did not differ from baseline levels after 12 weeks. In addition, plasma C-reactive protein level was decreased significantly in the rosiglitazone-treated group compared with values at baseline and for the untreated group after 12 weeks (0.73 +/- 0.09, 1.71 +/- 0.24, and 1.33 +/- 0.29 mg/L, respectively). Plasma level of monocyte chemoattractant protein 1 was decreased in the rosiglitazone group compared with the level at baseline (392 42 and 273 +/- 40 pg/mL, respectively). Moreover, the decrease in PWV was associated linearly both with improved homeostasis model assessment of insulin resistance and with decreased C-reactive protein level after PPAR-gamma agonist treatment. In conclusion, PPAR-gamma agonist rosiglitazone treatment may significantly decrease arterial stiffness in diabetic patients with CAD. Proliferator-activated receptor gamma agonists may play an important role in protecting against arteriosclerosis by normalizing the metabolic disorders and depressing chronic inflammation of the vascular system in patients with type 2 diabetes mellitus and serious vascular disease. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000249843100015
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62848
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Dept Cardiovasc Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci Minist Educ, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yu, Jie,Jin, Nan,Wang, Guang,et al. Peroxisome proliferator - activate receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery disease[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2007,56(10):1396-1401.
APA Yu, Jie,Jin, Nan,Wang, Guang,Zhang, Fuchun,Mao, Jieming,&Wang, Xian.(2007).Peroxisome proliferator - activate receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery disease.METABOLISM-CLINICAL AND EXPERIMENTAL,56(10),1396-1401.
MLA Yu, Jie,et al."Peroxisome proliferator - activate receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery disease".METABOLISM-CLINICAL AND EXPERIMENTAL 56.10(2007):1396-1401.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Jie]的文章
[Jin, Nan]的文章
[Wang, Guang]的文章
百度学术
百度学术中相似的文章
[Yu, Jie]的文章
[Jin, Nan]的文章
[Wang, Guang]的文章
必应学术
必应学术中相似的文章
[Yu, Jie]的文章
[Jin, Nan]的文章
[Wang, Guang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。