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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Peroxisome proliferator - activate receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery disease
作者: Yu, Jie; Jin, Nan; Wang, Guang; Zhang, Fuchun; Mao, Jieming; Wang, Xian
刊名: METABOLISM-CLINICAL AND EXPERIMENTAL
发表日期: 2007-10-01
DOI: 10.1016/j.metabot.2007.05.011
卷: 56, 期:10, 页:1396-1401
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: GENE-EXPRESSION ; PPAR-GAMMA ; IN-VITRO ; PIOGLITAZONE ; ROSIGLITAZONE ; INFLAMMATION ; VESSELS ; GROWTH ; PART
英文摘要:

Arterial stiffness is an independent risk factor for cardiovascular events in diabetic patients, and it can be assessed by measuring pulse wave velocity (PWV). We investigated the degree of arterial stiffness in diabetic patients with coronary artery disease (CAD) and the effect of the proliferator-activated receptor gamma (PPAR-gamma) agonist rosiglitazone on arterial stiffness in the potential mechanism of anti-arteriosclerosis in patients with type 2 diabetes mellitus and CAD. The 123 participants were divided into 3 groups: healthy controls (n = 36), diabetic patients (n = 41), and diabetic patients with CAD (n = 46). Forty-six diabetic patients with CAD were randomly divided into 2 groups: untreated diabetic patients with CAD and diabetic patients with CAD treated with 4 mg/d of rosiglitazone (n = 25) for 12 weeks. Pulse wave velocity was measured before treatment and at 12-week follow-up. Baseline PWV was significantly higher in patients with diabetes, diabetes and CAD. and diabetes and CAD with treatment as compared with the healthy control group (1633 +/- 37.3, 1669 +/- 53.8, 1615 +/- 44.4, and 1360 +/- 39.9 cm/s. respectively. P <.001). Pulse wave velocity in the rosiglitazone-treated group was significantly reduced, from 1615 +/- 44.4 to 1525 +/- 43.1 cm/s. after 12-week treatment, Furthermore, PWV was significantly decreased in the rosiglitazone-treated group compared with untreated group after 12 weeks (1525 +/- 43.1 and 1670 +/- 41.3 cm/s, respectively). Pulse wave velocity in the untreated group did not differ from baseline levels after 12 weeks. In addition, plasma C-reactive protein level was decreased significantly in the rosiglitazone-treated group compared with values at baseline and for the untreated group after 12 weeks (0.73 +/- 0.09, 1.71 +/- 0.24, and 1.33 +/- 0.29 mg/L, respectively). Plasma level of monocyte chemoattractant protein 1 was decreased in the rosiglitazone group compared with the level at baseline (392 42 and 273 +/- 40 pg/mL, respectively). Moreover, the decrease in PWV was associated linearly both with improved homeostasis model assessment of insulin resistance and with decreased C-reactive protein level after PPAR-gamma agonist treatment. In conclusion, PPAR-gamma agonist rosiglitazone treatment may significantly decrease arterial stiffness in diabetic patients with CAD. Proliferator-activated receptor gamma agonists may play an important role in protecting against arteriosclerosis by normalizing the metabolic disorders and depressing chronic inflammation of the vascular system in patients with type 2 diabetes mellitus and serious vascular disease. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000249843100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62848
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiovasc Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Yu, Jie,Jin, Nan,Wang, Guang,et al. Peroxisome proliferator - activate receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery disease[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2007,56(10):1396-1401.
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