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学科主题临床医学
Correlation of cervical intraepithelial neoplasia with expressions of p16 and Ki67 in exfoliated cervical cells in fluid-based thin-layer samples
You, K.; Guo, Y. L.; Geng, L.; Qiao, J.
关键词p16 Ki67 CIN HPV
刊名EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
2013
34期:6页:535-539
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]HUMAN-PAPILLOMAVIRUS ; P16(INK4A) EXPRESSION ; UTERINE CERVIX ; FOLLOW-UP ; HIGH-RISK ; KI-67 ; CANCER ; PROTEIN ; WOMEN ; OVEREXPRESSION
英文摘要

Objective: To understand the correlation of cervical intraepithelial neoplasia (CIN) with the expressions of p16 and Ki67 in exfoliated cervical cells obtained by fluid-based thin-layer technology. Study design: The distributions of p16 and Ki67 positive cells in 116 patients with cytologically diagnosed atypical squamous cells of undetermined significance (ASC-US) or human papilloma virus (HPV) positive were examined by immunocytochemistry. Data were analyzed by the rank sum test, crosstab test, and receiver operating characteristic (ROC) curves. Results: When the thresholds for p16 and Ki67 positive were set as 6.5 and 4.5 positive cells per 100 exfoliated cervical cells, respectively, the expressions of Ki67 and P16 are significantly higher in the exfoliated cervical cells of patients with CIN II or greater compared with those in patients with CIN I or less. Conclusion: Immunocytochemical examination of p16 and Ki67 expressions in the exfoliated cervical cells of fluid-based thin-layer samples could be used for the detection of CIN II or greater.

语种英语
WOS记录号WOS:000341555600007
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62849
专题北京大学第三临床医学院_妇产科
作者单位Peking Univ, Dept Gynecol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
You, K.,Guo, Y. L.,Geng, L.,et al. Correlation of cervical intraepithelial neoplasia with expressions of p16 and Ki67 in exfoliated cervical cells in fluid-based thin-layer samples[J]. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,2013,34(6):535-539.
APA You, K.,Guo, Y. L.,Geng, L.,&Qiao, J..(2013).Correlation of cervical intraepithelial neoplasia with expressions of p16 and Ki67 in exfoliated cervical cells in fluid-based thin-layer samples.EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,34(6),535-539.
MLA You, K.,et al."Correlation of cervical intraepithelial neoplasia with expressions of p16 and Ki67 in exfoliated cervical cells in fluid-based thin-layer samples".EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 34.6(2013):535-539.
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