北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 妇产科  > 期刊论文
学科主题: 临床医学
题名:
Correlation of cervical intraepithelial neoplasia with expressions of p16 and Ki67 in exfoliated cervical cells in fluid-based thin-layer samples
作者: You, K.; Guo, Y. L.; Geng, L.; Qiao, J.
关键词: p16 ; Ki67 ; CIN ; HPV
刊名: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
发表日期: 2013
卷: 34, 期:6, 页:535-539
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS ; P16(INK4A) EXPRESSION ; UTERINE CERVIX ; FOLLOW-UP ; HIGH-RISK ; KI-67 ; CANCER ; PROTEIN ; WOMEN ; OVEREXPRESSION
英文摘要:

Objective: To understand the correlation of cervical intraepithelial neoplasia (CIN) with the expressions of p16 and Ki67 in exfoliated cervical cells obtained by fluid-based thin-layer technology. Study design: The distributions of p16 and Ki67 positive cells in 116 patients with cytologically diagnosed atypical squamous cells of undetermined significance (ASC-US) or human papilloma virus (HPV) positive were examined by immunocytochemistry. Data were analyzed by the rank sum test, crosstab test, and receiver operating characteristic (ROC) curves. Results: When the thresholds for p16 and Ki67 positive were set as 6.5 and 4.5 positive cells per 100 exfoliated cervical cells, respectively, the expressions of Ki67 and P16 are significantly higher in the exfoliated cervical cells of patients with CIN II or greater compared with those in patients with CIN I or less. Conclusion: Immunocytochemical examination of p16 and Ki67 expressions in the exfoliated cervical cells of fluid-based thin-layer samples could be used for the detection of CIN II or greater.

语种: 英语
WOS记录号: WOS:000341555600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62849
Appears in Collections:北京大学第三临床医学院_妇产科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Gynecol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
You, K.,Guo, Y. L.,Geng, L.,et al. Correlation of cervical intraepithelial neoplasia with expressions of p16 and Ki67 in exfoliated cervical cells in fluid-based thin-layer samples[J]. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,2013,34(6):535-539.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[You, K.]'s Articles
[Guo, Y. L.]'s Articles
[Geng, L.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[You, K.]‘s Articles
[Guo, Y. L.]‘s Articles
[Geng, L.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace