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学科主题临床医学
Viability of frozen-thawed human embryos with one-two blastomeres lysis
Zheng, Xiaoying; Liu, Ping; Chen, Guian; Qiao, Jie; Wu, Yuqi; Fan, Ming
关键词blastomere loss embryo cryopreservation implantation
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2008-07-01
DOI10.1007/s10815-008-9224-3
25期:7页:281-285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]LASER-ASSISTED REMOVAL ; CLEAVAGE-STAGE EMBRYOS ; CRYOPRESERVED EMBRYOS ; NECROTIC BLASTOMERES ; CYCLES ; IMPLANTATION ; PARAMETERS ; SELECTION ; SURVIVAL ; INTACT
英文摘要

Objective To assess To assess the impact of one-two blastomeres lysis on the viability of thawed day 3 human embryos.

Methods A retrospective analysis was performed on 248 frozen-thawed embryo replacement cycles in which all embryos were frozen at day 3 at the seven-eight cell stage with <= 10% fragmentation.

Results Outcomes of transfer cycles with fully intact embryos (intact group) were compared with those in which all transferred embryos have lost one-two blastomeres (damage group). Comparable pregnancy rates (38.46% vs 38.64%), birth rates (34.62% vs 36.36%) and implantation rates (26.31% vs 26.25%) were obtained in intact and damage groups. These results were also not significantly different from mixed transfer cycles in which one intact embryo and one damaged embryo were transferred together.

Conclusion The developmental potential of partially damaged cryopreserved human embryos with less than 25% cells loss is comparable to that of fully intact embryos. Presence of one-two lysed blastomeres in the thawed day 3 embryo does not appear to have a negative influence on the further development of the sibling intact cells.

语种英语
WOS记录号WOS:000258614800001
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62852
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Third Hosp, Dept Ob & Gyn, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Xiaoying,Liu, Ping,Chen, Guian,et al. Viability of frozen-thawed human embryos with one-two blastomeres lysis[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2008,25(7):281-285.
APA Zheng, Xiaoying,Liu, Ping,Chen, Guian,Qiao, Jie,Wu, Yuqi,&Fan, Ming.(2008).Viability of frozen-thawed human embryos with one-two blastomeres lysis.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,25(7),281-285.
MLA Zheng, Xiaoying,et al."Viability of frozen-thawed human embryos with one-two blastomeres lysis".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 25.7(2008):281-285.
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