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学科主题临床医学
Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease
Li Shen1; Rao Xiang-rong1; Wang Su-xia2; Zhang Gai-hua1; Li Xiao-mei2; Dai Xi-wen1; Chen Ke-ji3
关键词primary glomerular diseases blood-stasis syndrome clinical index pathology of the renal biopsy
刊名CHINESE JOURNAL OF INTEGRATIVE MEDICINE
2009-06-01
DOI10.1007/s11655-009-0170-4
15期:3页:170-176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者Scientific Research Fund of State Administration of Traditional Chinese Medicine of the P. R. China ; Scientific Research Fund of State Administration of Traditional Chinese Medicine of the P. R. China
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]RENAL-DISEASE ; IGA NEPHROPATHY ; PROGRESSION ; PROTEINURIA
英文摘要

Objective: To investigate the relationship between the severity of Chinese medicine (CM) blood-stasis syndrome (BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods: An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases, and their severity of BSS were scored three days before renal biopsies were performed. The following clinical indexes were analyzed: age, course of glomerular diseases, 24-h urine protein ration (Upro), hypertension and blood pressure (BP) progress, serum creatinine levels (Scr), estimation of glomerular filtration rate based on the predigesting equation of MDRD (eGFR), blood urea nitrogen (BUN), uric acid (UA), triglyceride (TG), cholesterol (CHO), haematoglobin (HGB), albumin (ALB), and the correlation among renal pathological types, pathology lesion indexes, and BSS scores. Results: (1) Among the 227 patients, 207 (91.19%) were diagnosed as BSS, in which 95 cases were considered as moderate and the rest 112 cases as severe. (2) There was a negative correlation between age, gender, grades of the hypertension, and the BSS score. Multiple stepwise regression analysis showed that Upro, CHO, TG, and eGFR were positively related to the BSS score (P<0.05). (3) The BSS score has a positive correlation with indexes of chronic renal pathology, especially the tubular atrophy and interstitial fibrosis. The severity of proliferation and glomerular sclerosis was accompanied with higher BSS scores with a significant difference (P<0.05). Conclusions: BSS is one of the most common CM syndromes among patients with the primary glomerular diseases; the BSS score has a positive correlation with Upro, CHO, TG, eGFR, as well as the index of chronic renal pathology. Based on these observations, the BSS may be used as an indicator of the development of renal diseases. Being positively diagnosed as BSS could indicate the beginning of the chronic phase of the primary glomerular diseases.

语种英语
所属项目编号04-05JQ07
资助者Scientific Research Fund of State Administration of Traditional Chinese Medicine of the P. R. China ; Scientific Research Fund of State Administration of Traditional Chinese Medicine of the P. R. China
WOS记录号WOS:000266755800004
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62857
专题北京大学第一临床医学院_肾脏内科
作者单位1.China Acad Chinese Med Sci, Dept Nephrol, Guanganmen Hosp, Beijing 100053, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
3.China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China
推荐引用方式
GB/T 7714
Li Shen,Rao Xiang-rong,Wang Su-xia,et al. Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2009,15(3):170-176.
APA Li Shen.,Rao Xiang-rong.,Wang Su-xia.,Zhang Gai-hua.,Li Xiao-mei.,...&Chen Ke-ji.(2009).Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,15(3),170-176.
MLA Li Shen,et al."Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 15.3(2009):170-176.
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