IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Antimicrobial resistance trends among 5608 clinical Gram-positive isolates in China: results from the Gram-Positive Cocci Resistance Surveillance program (2005-2010)
Zhao, Chunjiang1; Sun, Hongli2; Wang, Hui1; Liu, Yudong2,14; Hu, Bijie3; Yu, Yunsong4,15; Sun, Ziyong5; Chu, Yunzhuo6; Cao, Bin7,8; Liao, Kang9; Lei, Jin′ e(10); Hu, Zhidong11; Zhang, Liyan12; Zhang, Xiaobing13; Xu, Yingchun2; Wang, Zhanwei1; Chen, Minjun2
关键词Resistance surveillance programs Methicillin-resistant Staphylococcus aureus (MRSA) Vancomycin-resistant enterococci Penicillin-resistant S. pneumoniae
刊名DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
2012-06-01
DOI10.1016/j.diagmicrobio.2012.03.003
73期:2页:174-181
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]STAPHYLOCOCCUS-AUREUS ; INFECTIONS ; ENTEROCOCCI ; DAPTOMYCIN ; HOSPITALS
英文摘要

A total of 5608 clinical isolates of Gram-positive bacteria were collected from 12 teaching hospitals across China from 2005 to 2010. The minimum inhibitory concentrations (MICs) of 19 antimicrobial agents were determined by the agar dilution method at the central laboratory. Overall, the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci (MRSCoN) were 46.8% and 81.5%, respectively. Isolates from inpatients exhibited a higher rate of MRSA than that from outpatients (52.3% versus 26.2%, P < 0.001). The prevalence of MRSA in respiratory infections (67.5%) was higher than in other sources of infections (P < 0.001). A shift in vancomycin MICs from <0.5 to 1.0 mu g/mL was observed during the 6-year period. In 2005, 70.5% of S. aureus isolates were inhibited at the vancomycin MIC of 0.5 mu g/mL., while in 2010, 89% of the isolates were inhibited at the vancomycin MIC of 1 mu g/mL. With the use of penicillin oral breakpoints, penicillin-resistant Streptococcus pneumoniae (PRSP) increased from 28.6% in 2005 to 59.5% in 2010 and varied among different age groups, with an average rate of 70.6% for children under 5 years old. Importantly, an obvious penicillin MIC right shift was observed from 0.032 to 4 mu g/mL during the study period. Serotyping for the isolates from 2005 and 2010 indicated that the high rate of PRSP could be due to the increased prevalence of serogroup 19. The prevalence of vancomycin-resistant enterococci (VRE) increased from 0 in 2005 to 4.9% in 2010. Of the 27 VRE isolates, vanA gene was the most prevalent gene. During the study period, 97.9-100% of different species tested were susceptible to teicoplanin. Linezolid and tigecycline showed potent activities, and no resistant isolate was identified. In conclusion, although the prevalence of MRSA and MRSCoN remained stable over the 6 years, a sharp increase in the prevalence of PRSP was identified. In addition, MIC shifts, including the MICs of penicillin against S. pneumoniae and vancomycin against S. aureus, were observed. Continuous surveillance is warranted to evaluate the resistance trend of clinically important Gram-positive organisms in the future. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000305102100013
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62859
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
2.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Shanghai 200032, Peoples R China
4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
6.China Med Univ, Hosp 1, Dept Clin Lab, Shenyang 110001, Peoples R China
7.Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing 100020, Peoples R China
8.Capital Med Univ, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing 100020, Peoples R China
9.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510080, Guangdong, Peoples R China
10.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Clin Lab, Xian 710061, Peoples R China
11.Tianjin Med Univ, Gen Hosp, Dept Clin Lab, Tianjin 300052, Peoples R China
12.Guangdong Gen Hosp, Dept Clin Lab, Guangzhou 510030, Guangdong, Peoples R China
13.Southwest Hosp, Dept Clin Lab, Chongqing 400038, Peoples R China
14.Univ Alabama Birmingham, Birmingham, AL 35294 USA
15.Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Chunjiang,Sun, Hongli,Wang, Hui,et al. Antimicrobial resistance trends among 5608 clinical Gram-positive isolates in China: results from the Gram-Positive Cocci Resistance Surveillance program (2005-2010)[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,2012,73(2):174-181.
APA Zhao, Chunjiang.,Sun, Hongli.,Wang, Hui.,Liu, Yudong.,Hu, Bijie.,...&Chen, Minjun.(2012).Antimicrobial resistance trends among 5608 clinical Gram-positive isolates in China: results from the Gram-Positive Cocci Resistance Surveillance program (2005-2010).DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,73(2),174-181.
MLA Zhao, Chunjiang,et al."Antimicrobial resistance trends among 5608 clinical Gram-positive isolates in China: results from the Gram-Positive Cocci Resistance Surveillance program (2005-2010)".DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 73.2(2012):174-181.
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