IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
T cell vaccination in systemic lupus erythematosus with autologous activated T cells
Li, ZG; Mu, R; Dai, ZP; Gao, XM
关键词systemic lupus erythematosus T cell vaccine therapeutics
刊名LUPUS
2005
DOI10.1191/0961203305lu2239oa
14期:11页:884-889
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]MULTIPLE-SCLEROSIS ; AUTOIMMUNE-DISEASES ; MURINE LUPUS ; REGION GENE ; MICE ; ARTHRITIS ; PROTEIN ; DNA ; NUCLEOSOME ; TOLERANCE
英文摘要

Systemic lupus erythematosus (SLE) is an autoreactive T cell mediated autoimmune disease. Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reaction to deplete specific subsets of autoreactive T cells involved in SLE. Six SLE patients unsuitable or refused to use immunosuppressants were treated with T cell vaccination. Their clinical manifestations and laboratory parameters including mixed lymphocyte reactions were evaluated. Autoreactive T cell clones were derived from peripheral blood mononuclear cells of the patients and 1 X 10(7) irradiated T cells were inoculated subcutaneously at 0, two, six and eight weeks, respectively. The enrolled patients were followed up for 32-40 months at an interval of three to six months. The clinical characteristics and laboratory abnormalities improved after inoculation without increasing the dose of corticosteroids and immunosuppressants in most patients. SLE disease activity index (SLEDAI) scores decreased. Proliferative responses against the T cell vaccine were observed in four of six patients. At the time of this report, the six patients remain in clinical remission. No significant side effect from the vaccination was noticed during the follow-up period. The results of this pilot study indicate that T cell vaccination is a safe and effective treatment in SLE.

语种英语
WOS记录号WOS:000233741100003
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62860
专题北京大学第二临床医学院
作者单位1.Beijing Univ, Sch Med, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Beijing Univ, Sch Med, Dept Immunol, Beijing 100044, Peoples R China
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GB/T 7714
Li, ZG,Mu, R,Dai, ZP,et al. T cell vaccination in systemic lupus erythematosus with autologous activated T cells[J]. LUPUS,2005,14(11):884-889.
APA Li, ZG,Mu, R,Dai, ZP,&Gao, XM.(2005).T cell vaccination in systemic lupus erythematosus with autologous activated T cells.LUPUS,14(11),884-889.
MLA Li, ZG,et al."T cell vaccination in systemic lupus erythematosus with autologous activated T cells".LUPUS 14.11(2005):884-889.
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