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学科主题: 临床医学
题名:
Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit
作者: Zhang, Pei-xun; A, Li-ya; Kou, Yu-hui; Yin, Xiao-feng; Xue, Feng; Han, Na; Wang, Tian-bing; Jiang, Bao-guo
关键词: nerve regeneration ; peripheral nerve ; small gap ; axons ; Schwann cells ; repair ; injury ; biological conduit ; NSFC grants ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015
DOI: 10.4103/1673-5374.150709
卷: 10, 期:1, 页:71-78
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: ELECTRICAL-STIMULATION ; FUNCTIONAL RECOVERY ; SCHWANN-CELLS ; PHENOTYPIC CHANGES ; CHITIN CONDUIT ; GUIDE ; REINNERVATION ; MUTILATION ; OUTGROWTH ; SURGERY
英文摘要:

The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair peripheral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good histocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve fibers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration (2-8 weeks), the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objective and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

语种: 英语
所属项目编号: 2014CB542200 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 30971526 ; 31100860 ; 31040043 ; 31371210 ; BMU20110270
项目资助者: National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China
WOS记录号: WOS:000350098100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62861
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Pei-xun,A, Li-ya,Kou, Yu-hui,et al. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit[J]. NEURAL REGENERATION RESEARCH,2015,10(1):71-78.
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