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学科主题: 临床医学
题名:
Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
作者: Zhao, Xiang-Yu1,2; Lv, Meng1,2; Xu, Ling-Ling1,2; Qian, Xin3,4; Huang, Xiao-Jun1,2
关键词: Chronic GVHD ; HSCT ; IL-21 ; Th17
刊名: EUROPEAN JOURNAL OF IMMUNOLOGY
发表日期: 2013-03-01
DOI: 10.1002/eji.201242816
卷: 43, 期:3, 页:838-850
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; COLONY-STIMULATING FACTOR ; ACUTE MYELOID-LEUKEMIA ; LYMPHOCYTE INFUSION ; RISK-FACTORS ; T-CELLS ; RELAPSE ; BLOOD ; DIFFERENTIATION ; GENERATION
英文摘要:

The roles of Th17 cells and IL-21 in the pathogenesis of chronic graft-versus-host disease (cGVHD) in patients who undergo allogeneic transplantation are still unknown. Here, we examined this question by monitoring eight patients with new-onset cGVHD for the presence of Th17 cells, Th1 cells, and IL-21. Allografts from an additional 41 patients were also analyzed for Th17 and Th1 cells. Out of these 41 patients, the last 32 enrolled patients were further analyzed for Th17 cells, Th1 cells, and plasma IL-21 levels at day 30 post-transplantation regarding cGVHD. Th17 cells and IL-21 plasma levels were significantly increased at cGVHD onset and drastically decreased after complete remission. Patients who received a higher number of Th17 cells in their allograft had a higher incidence of cGVHD compared with patients who received a lower number of Th17 cells. Meanwhile, positive plasma IL-21 levels at day 30 post-transplantation predicted cGVHD occurrence. These results suggest that Th17 cells and IL-21 may contribute to the development of cGVHD.

语种: 英语
所属项目编号: 81270644 ; 81230013 ; 2008B05 ; 7113171 ; 200800011087 ; 20110001110039 ; 2013CB733700
项目资助者: National Natural Science Foundation of China ; Beijing Novel Program ; Beijing Natural Science Foundation ; Ministry of Education of China ; Major State Basic Research Development Program of China (973 Program)
WOS记录号: WOS:000316140600028
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62864
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China
3.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fu Wai Hosp, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Zhao, Xiang-Yu,Lv, Meng,Xu, Ling-Ling,et al. Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2013,43(3):838-850.
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