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Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
Zhao, Xiang-Yu1,2; Lv, Meng1,2; Xu, Ling-Ling1,2; Qian, Xin3,4; Huang, Xiao-Jun1,2
关键词Chronic GVHD HSCT IL-21 Th17
刊名EUROPEAN JOURNAL OF IMMUNOLOGY
2013-03-01
DOI10.1002/eji.201242816
43期:3页:838-850
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; COLONY-STIMULATING FACTOR ; ACUTE MYELOID-LEUKEMIA ; LYMPHOCYTE INFUSION ; RISK-FACTORS ; T-CELLS ; RELAPSE ; BLOOD ; DIFFERENTIATION ; GENERATION
英文摘要

The roles of Th17 cells and IL-21 in the pathogenesis of chronic graft-versus-host disease (cGVHD) in patients who undergo allogeneic transplantation are still unknown. Here, we examined this question by monitoring eight patients with new-onset cGVHD for the presence of Th17 cells, Th1 cells, and IL-21. Allografts from an additional 41 patients were also analyzed for Th17 and Th1 cells. Out of these 41 patients, the last 32 enrolled patients were further analyzed for Th17 cells, Th1 cells, and plasma IL-21 levels at day 30 post-transplantation regarding cGVHD. Th17 cells and IL-21 plasma levels were significantly increased at cGVHD onset and drastically decreased after complete remission. Patients who received a higher number of Th17 cells in their allograft had a higher incidence of cGVHD compared with patients who received a lower number of Th17 cells. Meanwhile, positive plasma IL-21 levels at day 30 post-transplantation predicted cGVHD occurrence. These results suggest that Th17 cells and IL-21 may contribute to the development of cGVHD.

语种英语
WOS记录号WOS:000316140600028
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62864
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China
3.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fu Wai Hosp, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
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GB/T 7714
Zhao, Xiang-Yu,Lv, Meng,Xu, Ling-Ling,et al. Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2013,43(3):838-850.
APA Zhao, Xiang-Yu,Lv, Meng,Xu, Ling-Ling,Qian, Xin,&Huang, Xiao-Jun.(2013).Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation.EUROPEAN JOURNAL OF IMMUNOLOGY,43(3),838-850.
MLA Zhao, Xiang-Yu,et al."Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation".EUROPEAN JOURNAL OF IMMUNOLOGY 43.3(2013):838-850.
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