IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Feasibility study of exploring a T1-weighted dynamic contrast-enhanced MR approach for brain perfusion imaging
Zhang, Yudong1; Wang, Jing2; Wang, Xiaoying1,2; Zhang, Jue2,3; Fang, Jing2,3; Jiang, Xuexiang1
关键词brain perfusion cerebral blood flow cerebral blood volume dynamic contrast-enhanced MRI mean transit time
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2012-06-01
DOI10.1002/jmri.23570
35期:6页:1322-1331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]CEREBRAL-BLOOD-FLOW ; ARTERIAL INPUT FUNCTION ; MAGNETIC-RESONANCE ; PARTIAL VOLUME ; DECONVOLUTION ALGORITHMS ; QUANTITATIVE ASSESSMENT ; WATER EXCHANGE ; STEADY-STATE ; TRANSIT-TIME ; ACUTE STROKE
英文摘要

Purpose: To investigate the feasibility of T1-weighted dynamic contrast-enhanced (DCE) MRI for the measurement of brain perfusion. Materials and Methods: Dynamic imaging was performed on a 3.0 Tesla (T) MR scanner by using a rapid spoiled-GRE protocol. T1 measurement with driven equilibrium single pulse observation of T1 (DESPOT1) was used to convert the MR signal to tracer concentration. Cerebral perfusion maps were obtained by using an improved gamma-variate model in 10 subjects and compared with those with arterial spin label (ASL) approach. Results: The cerebral blood volume (CBV) values were calculated as 4.74 +/- 1.09 and 2.29 +/- 0.58 mL/100 g in gray matter (GM) and whiter matter (WM), respectively. Mean transit time (MTT) values were 6.15 +/- 0.59 s in GM and 6.96 +/- 0.79 s in WM. The DCE values for GM/WM cerebral blood flow (CBF) were measured as 53.41 +/- 9.23 / 25.78 +/- 8.91 mL/100 g/min, versus ASL values of 49.05 +/- 10.81 / 23.00 +/- 5.89 mL/100 g/min for GW/WM. Bland-Altman plot revealed a small difference of CBF between two approaches (mean bias = 3.83 mL/100 g/min, SD = 11.29). There were 6 pairs of samples (5%, 6/120) beyond the 95% limits of agreement. The correlation plots showed that the slop of Y (CBF_DCE) versus X intercept (CBF_ASL) is 0.95 with the intercept of 4.53 mL/100 g/min (r = 0.74; P < 0.05). Conclusion: It is feasible to evaluate the cerebral perfusion by using T1-weighted DCE-MRI with the improved kinetic model. J. Magn. Reson. Imaging 2012;. (c) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000304035100008
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62869
Collection北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yudong,Wang, Jing,Wang, Xiaoying,et al. Feasibility study of exploring a T1-weighted dynamic contrast-enhanced MR approach for brain perfusion imaging[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2012,35(6):1322-1331.
APA Zhang, Yudong,Wang, Jing,Wang, Xiaoying,Zhang, Jue,Fang, Jing,&Jiang, Xuexiang.(2012).Feasibility study of exploring a T1-weighted dynamic contrast-enhanced MR approach for brain perfusion imaging.JOURNAL OF MAGNETIC RESONANCE IMAGING,35(6),1322-1331.
MLA Zhang, Yudong,et al."Feasibility study of exploring a T1-weighted dynamic contrast-enhanced MR approach for brain perfusion imaging".JOURNAL OF MAGNETIC RESONANCE IMAGING 35.6(2012):1322-1331.
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