IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Bone marrow stromal cells differentiated into functional Schwann cells in injured rats sciatic nerve
Zhang, PX; He, XJ; Liu, KY; Zhao, FQ; Fu, ZG; Zhang, DY; Zhang, Q; Jiang, BG
关键词bone marrow stromal cells differentiation Schwann cells
刊名ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
2004
DOI10.1081/LABB-200039608
32期:4页:509-518
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]STEM-CELLS ; IN-VITRO ; REGENERATION ; TRANSPLANTATION ; ENGRAFTMENT ; BRAINS
英文摘要

Bone marrow stromal cells (MSCs) have been shown to differentiate into various lineage cells including neural cells in vitro and in vivo. We therefore examined whether MSCs can differentiate into Schwann cells in injured peripheral nerves. After cultured in vitro, PKH-67-labeled MSCs were injected into the mechanically injured rat sciatic nerves. Three weeks after injection, immunofluorescent examinations were carried out. MSCs had been incorporated around the injured nerves and differentiated into Schwann cells. MSCs had accumulated mainly in the epineurium around the injured nerve. The incorporated cells partially expressed GFAP, S-100, and P75. These results confirmed the possibility that MSCs have the ability to differentiate into Schwann cells, and that injection of MSCs into the injured peripheral nerve would help repair damaged nerve.

语种英语
WOS记录号WOS:000225928600003
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62879
专题北京大学第二临床医学院
作者单位Peking Univ, Coll Med, People Hosp, Traumat Bone Dept, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhang, PX,He, XJ,Liu, KY,et al. Bone marrow stromal cells differentiated into functional Schwann cells in injured rats sciatic nerve[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2004,32(4):509-518.
APA Zhang, PX.,He, XJ.,Liu, KY.,Zhao, FQ.,Fu, ZG.,...&Jiang, BG.(2004).Bone marrow stromal cells differentiated into functional Schwann cells in injured rats sciatic nerve.ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,32(4),509-518.
MLA Zhang, PX,et al."Bone marrow stromal cells differentiated into functional Schwann cells in injured rats sciatic nerve".ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 32.4(2004):509-518.
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