|Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women|
|Ouyang, Fengxiu1,2,3; Necheles, Jonathan1,2,3,4; Wang, Binyan1,2,3; Ma, Wei5; Li, Zhiping6; Liu, Xue6; Tang, Genfu6; Xing, Houxun6; Xu, Xiping7; Venners, Scott A.7; Brickman, Wendy J.2,8; Christoffel, Katherine Kaufer1,2,3,4; Zimmerman, Donald2,8; Wang, Xiaobin1,2,3|
|关键词||Body mass index Waist circumference Body composition Metabolic syndrome Chinese women Twins|
|刊名||EUROPEAN JOURNAL OF NUTRITION|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics|
|研究领域[WOS]||Nutrition & Dietetics|
|关键词[WOS]||BODY-MASS INDEX ; INTERNATIONAL-DIABETES-FEDERATION ; CARDIOVASCULAR RISK ; BLOOD-PRESSURE ; WAIST CIRCUMFERENCE ; INSULIN-RESISTANCE ; VISCERAL FAT ; YOUNG-ADULTS ; PREVALENCE ; OBESITY|
Most studies linking obesity and metabolic syndrome (MS) have used body mass index (BMI) and waist circumference (WC) to measure obesity. While BMI is correlated with direct measures of total and central adiposity, it is influenced by lean body and bone mass. We hypothesize that direct measures of adiposity may help develop further insight into the link between obesity and MS, thus more accurately identifying individuals at high risk for MS.
We examined how surrogate and direct measures of adiposity were associated with MS risk and if direct adiposity measures enhanced BMI and WC identification of MS risk.
3,734 Chinese female twins aged 20-39 years were studied. Percent body fat (%BF) and proportion of trunk fat to total BF (%TF) were assessed by DEXA. Graphic plots and generalized estimating equations were used to examine the associations of adiposity measures with MS and its components. Concordance of adiposity measures and MS abnormalities between monozygotic (MZ) and dizygotic (DZ) twin pairs were compared.
The prevalence of MS increased for high BMI (a parts per thousand yen23 kg/m(2)), %BF (a parts per thousand yen32), WC (a parts per thousand yen80 cm), and (to a lesser degree) %TF (a parts per thousand yen50). Below those thresholds, the prevalence of MS was low (0-5.3%). %TF was independently associated with higher risk of MS and its components even after adjusting for BMI and WC. As a result, among women with normal BMI and WC, high %TF was associated with 1.3-2.0-fold elevated risk of MS components. In contrast, women with high BMI but normal WC and %TF neither have significantly increased risk of MS, nor for any component other than high BP. MZ twins showed higher concordance for MS and its components than DZ twins.
In this lean Chinese rural female sample, BMI a parts per thousand yen 23 and WC a parts per thousand yen 80 were associated with a markedly increased risk of MS, which was further enhanced by elevated %TF. Even in women with a normal BMI and WC, %TF was independently associated with MS and its components. Twin analysis findings suggest that adiposity measurements and MS risk are influenced by genetics.
|项目编号||R01 HD049059 ; R01 HL0864619 ; R01 AG032227 ; K01 ES012052|
|资助机构||National Institute of Child Health and Human Development ; National Heart, Lung, and Blood Institute ; National Institute of Aging ; National Institute of Environmental Health Sciences ; Food Allergy Project|
|作者单位||1.Childrens Mem Hosp, Chicago, IL 60614 USA|
2.Childrens Mem Res Ctr, Chicago, IL 60614 USA
3.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
4.Northwestern Univ, Feinberg Sch Med, Dept Pediat, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
5.Northwestern Univ, Feinberg Sch Med, Div Gen Acad Pediat, Chicago, IL 60614 USA
6.Beijing Univ, Affiliated Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
7.Univ Illinois, Sch Publ Hlth, Ctr Populat Genet, Chicago, IL USA
8.Northwestern Univ, Feinberg Sch Med, Dept Pediat, Div Endocrinol, Chicago, IL 60614 USA
|Ouyang, Fengxiu,Necheles, Jonathan,Wang, Binyan,et al. Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women[J]. EUROPEAN JOURNAL OF NUTRITION,2009,48(6):323-332.|
|APA||Ouyang, Fengxiu.,Necheles, Jonathan.,Wang, Binyan.,Ma, Wei.,Li, Zhiping.,...&Wang, Xiaobin.(2009).Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women.EUROPEAN JOURNAL OF NUTRITION,48(6),323-332.|
|MLA||Ouyang, Fengxiu,et al."Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women".EUROPEAN JOURNAL OF NUTRITION 48.6(2009):323-332.|