IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women
Ouyang, Fengxiu1,2,3; Necheles, Jonathan1,2,3,4; Wang, Binyan1,2,3; Ma, Wei5; Li, Zhiping6; Liu, Xue6; Tang, Genfu6; Xing, Houxun6; Xu, Xiping7; Venners, Scott A.7; Brickman, Wendy J.2,8; Christoffel, Katherine Kaufer1,2,3,4; Zimmerman, Donald2,8; Wang, Xiaobin1,2,3
关键词Body mass index Waist circumference Body composition Metabolic syndrome Chinese women Twins
刊名EUROPEAN JOURNAL OF NUTRITION
2009-09-01
DOI10.1007/s00394-009-0016-z
48期:6页:323-332
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]BODY-MASS INDEX ; INTERNATIONAL-DIABETES-FEDERATION ; CARDIOVASCULAR RISK ; BLOOD-PRESSURE ; WAIST CIRCUMFERENCE ; INSULIN-RESISTANCE ; VISCERAL FAT ; YOUNG-ADULTS ; PREVALENCE ; OBESITY
英文摘要

Most studies linking obesity and metabolic syndrome (MS) have used body mass index (BMI) and waist circumference (WC) to measure obesity. While BMI is correlated with direct measures of total and central adiposity, it is influenced by lean body and bone mass. We hypothesize that direct measures of adiposity may help develop further insight into the link between obesity and MS, thus more accurately identifying individuals at high risk for MS.

We examined how surrogate and direct measures of adiposity were associated with MS risk and if direct adiposity measures enhanced BMI and WC identification of MS risk.

3,734 Chinese female twins aged 20-39 years were studied. Percent body fat (%BF) and proportion of trunk fat to total BF (%TF) were assessed by DEXA. Graphic plots and generalized estimating equations were used to examine the associations of adiposity measures with MS and its components. Concordance of adiposity measures and MS abnormalities between monozygotic (MZ) and dizygotic (DZ) twin pairs were compared.

The prevalence of MS increased for high BMI (a parts per thousand yen23 kg/m(2)), %BF (a parts per thousand yen32), WC (a parts per thousand yen80 cm), and (to a lesser degree) %TF (a parts per thousand yen50). Below those thresholds, the prevalence of MS was low (0-5.3%). %TF was independently associated with higher risk of MS and its components even after adjusting for BMI and WC. As a result, among women with normal BMI and WC, high %TF was associated with 1.3-2.0-fold elevated risk of MS components. In contrast, women with high BMI but normal WC and %TF neither have significantly increased risk of MS, nor for any component other than high BP. MZ twins showed higher concordance for MS and its components than DZ twins.

In this lean Chinese rural female sample, BMI a parts per thousand yen 23 and WC a parts per thousand yen 80 were associated with a markedly increased risk of MS, which was further enhanced by elevated %TF. Even in women with a normal BMI and WC, %TF was independently associated with MS and its components. Twin analysis findings suggest that adiposity measurements and MS risk are influenced by genetics.

语种英语
WOS记录号WOS:000269917300001
项目编号R01 HD049059 ; R01 HL0864619 ; R01 AG032227 ; K01 ES012052
资助机构National Institute of Child Health and Human Development ; National Heart, Lung, and Blood Institute ; National Institute of Aging ; National Institute of Environmental Health Sciences ; Food Allergy Project
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62883
专题北京大学第一临床医学院_心血管内科
作者单位1.Childrens Mem Hosp, Chicago, IL 60614 USA
2.Childrens Mem Res Ctr, Chicago, IL 60614 USA
3.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
4.Northwestern Univ, Feinberg Sch Med, Dept Pediat, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
5.Northwestern Univ, Feinberg Sch Med, Div Gen Acad Pediat, Chicago, IL 60614 USA
6.Beijing Univ, Affiliated Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
7.Univ Illinois, Sch Publ Hlth, Ctr Populat Genet, Chicago, IL USA
8.Northwestern Univ, Feinberg Sch Med, Dept Pediat, Div Endocrinol, Chicago, IL 60614 USA
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GB/T 7714
Ouyang, Fengxiu,Necheles, Jonathan,Wang, Binyan,et al. Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women[J]. EUROPEAN JOURNAL OF NUTRITION,2009,48(6):323-332.
APA Ouyang, Fengxiu.,Necheles, Jonathan.,Wang, Binyan.,Ma, Wei.,Li, Zhiping.,...&Wang, Xiaobin.(2009).Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women.EUROPEAN JOURNAL OF NUTRITION,48(6),323-332.
MLA Ouyang, Fengxiu,et al."Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women".EUROPEAN JOURNAL OF NUTRITION 48.6(2009):323-332.
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