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IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科  > 期刊论文
学科主题: 临床医学
题名:
Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning
作者: Zhang, Jizhun1; Jiang, Kewei1; Lv, Liang1; Wang, Hui2; Shen, Zhanlong1; Gao, Zhidong1; Wang, Bo1; Yang, Yang1; Ye, Yingjiang1; Wang, Shan1
刊名: PLOS ONE
发表日期: 2015-03-24
DOI: 10.1371/journal.pone.0116477
卷: 10, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CHROMATIN MARKS ; RESOURCE ; TARGETS ; IDENTIFICATION ; VARIANTS ; GENETICS ; DATABASE ; CATALOG ; TRAITS ; GWAS
英文摘要:

Although genome-wide association studies have identified many risk loci associated with colorectal cancer, the molecular basis of these associations are still unclear. We aimed to infer biological insights and highlight candidate genes of interest within GWAS risk loci. We used an in silico pipeline based on functional annotation, quantitative trait loci mapping of cis-acting gene, PubMed text-mining, protein-protein interaction studies, genetic overlaps with cancer somatic mutations and knockout mouse phenotypes, and functional enrichment analysis to prioritize the candidate genes at the colorectal cancer risk loci. Based on these analyses, we observed that these genes were the targets of approved therapies for colorectal cancer, and suggested that drugs approved for other indications may be repurposed for the treatment of colorectal cancer. This study highlights the use of publicly available data as a cost effective solution to derive biological insights, and provides an empirical evidence that the molecular basis of colorectal cancer can provide important leads for the discovery of new drugs.

语种: 英语
所属项目编号: 2104000032 ; 81372290 ; 81372291
项目资助者: National Key Technology Support Program ; National Natural Science Foundation of China
WOS记录号: WOS:000353889600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62886
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Jizhun,Jiang, Kewei,Lv, Liang,et al. Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning[J]. PLOS ONE,2015,10(3).
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