IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning
Zhang, Jizhun1; Jiang, Kewei1; Lv, Liang1; Wang, Hui2; Shen, Zhanlong1; Gao, Zhidong1; Wang, Bo1; Yang, Yang1; Ye, Yingjiang1; Wang, Shan1
刊名PLOS ONE
2015-03-24
DOI10.1371/journal.pone.0116477
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CHROMATIN MARKS ; RESOURCE ; TARGETS ; IDENTIFICATION ; VARIANTS ; GENETICS ; DATABASE ; CATALOG ; TRAITS ; GWAS
英文摘要

Although genome-wide association studies have identified many risk loci associated with colorectal cancer, the molecular basis of these associations are still unclear. We aimed to infer biological insights and highlight candidate genes of interest within GWAS risk loci. We used an in silico pipeline based on functional annotation, quantitative trait loci mapping of cis-acting gene, PubMed text-mining, protein-protein interaction studies, genetic overlaps with cancer somatic mutations and knockout mouse phenotypes, and functional enrichment analysis to prioritize the candidate genes at the colorectal cancer risk loci. Based on these analyses, we observed that these genes were the targets of approved therapies for colorectal cancer, and suggested that drugs approved for other indications may be repurposed for the treatment of colorectal cancer. This study highlights the use of publicly available data as a cost effective solution to derive biological insights, and provides an empirical evidence that the molecular basis of colorectal cancer can provide important leads for the discovery of new drugs.

语种英语
WOS记录号WOS:000353889600004
项目编号2104000032 ; 81372290 ; 81372291
资助机构National Key Technology Support Program ; National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62886
专题北京大学第二临床医学院_胃肠外科
作者单位1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jizhun,Jiang, Kewei,Lv, Liang,et al. Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning[J]. PLOS ONE,2015,10(3).
APA Zhang, Jizhun.,Jiang, Kewei.,Lv, Liang.,Wang, Hui.,Shen, Zhanlong.,...&Wang, Shan.(2015).Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning.PLOS ONE,10(3).
MLA Zhang, Jizhun,et al."Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning".PLOS ONE 10.3(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Jizhun]的文章
[Jiang, Kewei]的文章
[Lv, Liang]的文章
百度学术
百度学术中相似的文章
[Zhang, Jizhun]的文章
[Jiang, Kewei]的文章
[Lv, Liang]的文章
必应学术
必应学术中相似的文章
[Zhang, Jizhun]的文章
[Jiang, Kewei]的文章
[Lv, Liang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。