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Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death
Zhao, Ying1; Wang, Lina1; Yang, Jing1; Zhang, Ping1; Ma, Ke1; Zhou, Jingyi1; Liao, Wenjuan1; Zhu, Wei-Guo1,2
关键词autophagy FoxO1 SIRT2 Atg7 cell death
刊名AUTOPHAGY
2010-10-01
DOI10.4161/auto.6.7.13289
6期:7页:988-990
收录类别SCI
文章类型Editorial Material
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
英文摘要

Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead 0 family protein, is a mediator of autophagy. Upon oxidative stress or serum starvation, endogenous FoxO1 was required for autophagy in human cancer cell lines, and this process was independent of FoxO1′s transcriptional activity as well as mTOR or Beclin 1. In response to stress, FoxO1 dissociated from an NAD(+)-dependent histone deacetylase SIRT2 and FoxO1 thus became acetylated and in turn bound to Atg7, an El-like protein, to influence the autophagic process leading to cell death. In particular, cytosolic FoxO1 suppressed tumor xenograft growth in nude mice in an autophagy-dependent manner. Our studies provide evidence that cytosolic FoxO1-induced autophagy is associated with tumor suppression function.

语种英语
WOS记录号WOS:000282705400029
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62888
专题北京大学临床肿瘤学院
北京大学基础医学院
北京大学第二临床医学院_妇科
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Oncol, Beijing 100871, Peoples R China
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GB/T 7714
Zhao, Ying,Wang, Lina,Yang, Jing,et al. Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death[J]. AUTOPHAGY,2010,6(7):988-990.
APA Zhao, Ying.,Wang, Lina.,Yang, Jing.,Zhang, Ping.,Ma, Ke.,...&Zhu, Wei-Guo.(2010).Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death.AUTOPHAGY,6(7),988-990.
MLA Zhao, Ying,et al."Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death".AUTOPHAGY 6.7(2010):988-990.
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