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学科主题: 药学
题名:
Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery
作者: Zou, Aifeng1; Huo, Meirong1; Zhang, Yong1; Zhou, Jianping1; Yin, Xiaoqiang1; Yao, Chengli1; Zhu, Qinnv1; Zhang, Min2; Ren, Jinshan2; Zhang, Qiang3
关键词: chitosan ; polymeric drug delivery system ; drug targeting ; micelle ; cancer chemotherapy
刊名: JOURNAL OF PHARMACEUTICAL SCIENCES
发表日期: 2012-02-01
DOI: 10.1002/jps.22798
卷: 101, 期:2, 页:627-640
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: LUNG-CANCER CELLS ; POLYMERIC MICELLES ; DOXORUBICIN DELIVERY ; CONJUGATES INHIBIT ; BLOCK-COPOLYMERS ; IN-VITRO ; NANOPARTICLES ; PROTEINS ; FAMILY ; DERIVATIVES
英文摘要:

Octreotide (OCT) was recently found to have high binding affinity to the positive tumor cells of somatostatin receptors (SSTRs). In this study, octreotidePhepolyethylene glycolstearic acid was first successfully synthesized and used as a targeting molecule for N-octyl-O, N-carboxymethyl chitosan (OCC). Doxorubicin (DOX) was loaded into OCT-modified OCC micelles (DOXOCCOCT). The drug-loaded micelles obtained exhibited spherical shape, small particle sizes, and negative zeta potentials. The cytotoxicity of DOXOCCOCT micelles against MCF-7 cells (SSTRs expressing) was found to significantly increase with the increased amount of OCT modification, whereas no significant difference was observed against WI-38 cells (no SSTRs expressing). Results of flow cytometry, fluorescence microscopy, and confocal laser scanning microscopy confirmed that DOXOCCOCT micelles could remarkably increase the uptake of DOX in MCF-7 cells. All the results indicated that OCCOCT micelles may be a promising intracellular targeting carrier for efficient delivery of antitumor drugs into tumor cells. (C) 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:627640, 2012

语种: 英语
所属项目编号: BK2007173 ; 200803161017 ; 2009ZX09310004 ; 81102397 ; 2009CB903300
项目资助者: Natural Science Foundation of Jiangsu Province ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Ministry of Science and Technology, China ; National Science Foundation of China ; Nanjing Welman Institute of Materia Medica ; new foundation of National Basic Research Program of China (973 Program)
WOS记录号: WOS:000298475400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62889
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Nanjing Welman Inst Mat Med, Nanjing 210009, Peoples R China
2.China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zou, Aifeng,Huo, Meirong,Zhang, Yong,et al. Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2012,101(2):627-640.
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