IR@PKUHSC  > 北京大学药学院
学科主题药学
Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery
Zou, Aifeng1; Huo, Meirong1; Zhang, Yong1; Zhou, Jianping1; Yin, Xiaoqiang1; Yao, Chengli1; Zhu, Qinnv1; Zhang, Min2; Ren, Jinshan2; Zhang, Qiang3
关键词chitosan polymeric drug delivery system drug targeting micelle cancer chemotherapy
刊名JOURNAL OF PHARMACEUTICAL SCIENCES
2012-02-01
DOI10.1002/jps.22798
101期:2页:627-640
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]LUNG-CANCER CELLS ; POLYMERIC MICELLES ; DOXORUBICIN DELIVERY ; CONJUGATES INHIBIT ; BLOCK-COPOLYMERS ; IN-VITRO ; NANOPARTICLES ; PROTEINS ; FAMILY ; DERIVATIVES
英文摘要

Octreotide (OCT) was recently found to have high binding affinity to the positive tumor cells of somatostatin receptors (SSTRs). In this study, octreotidePhepolyethylene glycolstearic acid was first successfully synthesized and used as a targeting molecule for N-octyl-O, N-carboxymethyl chitosan (OCC). Doxorubicin (DOX) was loaded into OCT-modified OCC micelles (DOXOCCOCT). The drug-loaded micelles obtained exhibited spherical shape, small particle sizes, and negative zeta potentials. The cytotoxicity of DOXOCCOCT micelles against MCF-7 cells (SSTRs expressing) was found to significantly increase with the increased amount of OCT modification, whereas no significant difference was observed against WI-38 cells (no SSTRs expressing). Results of flow cytometry, fluorescence microscopy, and confocal laser scanning microscopy confirmed that DOXOCCOCT micelles could remarkably increase the uptake of DOX in MCF-7 cells. All the results indicated that OCCOCT micelles may be a promising intracellular targeting carrier for efficient delivery of antitumor drugs into tumor cells. (C) 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:627640, 2012

语种英语
WOS记录号WOS:000298475400020
项目编号BK2007173 ; 200803161017 ; 2009ZX09310004 ; 81102397 ; 2009CB903300
资助机构Natural Science Foundation of Jiangsu Province ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Ministry of Science and Technology, China ; National Science Foundation of China ; Nanjing Welman Institute of Materia Medica ; new foundation of National Basic Research Program of China (973 Program)
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62889
专题北京大学药学院
作者单位1.Nanjing Welman Inst Mat Med, Nanjing 210009, Peoples R China
2.China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zou, Aifeng,Huo, Meirong,Zhang, Yong,et al. Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2012,101(2):627-640.
APA Zou, Aifeng.,Huo, Meirong.,Zhang, Yong.,Zhou, Jianping.,Yin, Xiaoqiang.,...&Zhang, Qiang.(2012).Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery.JOURNAL OF PHARMACEUTICAL SCIENCES,101(2),627-640.
MLA Zou, Aifeng,et al."Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery".JOURNAL OF PHARMACEUTICAL SCIENCES 101.2(2012):627-640.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zou, Aifeng]的文章
[Huo, Meirong]的文章
[Zhang, Yong]的文章
百度学术
百度学术中相似的文章
[Zou, Aifeng]的文章
[Huo, Meirong]的文章
[Zhang, Yong]的文章
必应学术
必应学术中相似的文章
[Zou, Aifeng]的文章
[Huo, Meirong]的文章
[Zhang, Yong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。