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学科主题: 药学
题名:
Preparation and characterization of silybin-loaded nanostructured lipid carriers
作者: Jia, Le-Jiao1; Zhang, Dian-Rui1; Li, Zhen-Yu2; Feng, Fei-Fei1; Wang, Yan-Cai1; Dai, Weil-Ting1; Duan, Cun-Xian1; Zhang, Qiang3
关键词: Nanostructured lipid carriers ; Silybin ; differential scanning calorimetry ; X-ray diffraction ; in vitro release
刊名: DRUG DELIVERY
发表日期: 2010
DOI: 10.3109/10717540903431586
卷: 17, 期:1, 页:11-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NANOPARTICLES SLN ; ELECTRON-MICROSCOPY ; BODY DISTRIBUTION ; MILK THISTLE ; SPECTROSCOPY ; DELIVERY ; MARIANUM ; SYSTEM ; NLC
英文摘要:

Nanostructured lipid carriers (NLC) are a new generation of lipid nanoparticles, which are produced by controlled mixing of solid lipids with spatially incompatible liquid lipids leading to special nanostructures with improved drug incorporation and release properties. In this study, silybin-loaded nanostructured lipid carriers with various liquid lipid content were successfully prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The size and morphology of nanoparticles were significantly influenced by the liquid lipid content. As the liquid lipid content increased to 20 wt%, the obtained particles showed distinguished smaller size. Compared with solid lipid nanoparticles (SLN), NLC presented improved drug loading capacity which increased with increasing the liquid lipid content. The differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis indicated that the incorporation of liquid lipids could interfere with the crystallization of solid lipids. The drug in vitro release behavior from NLC displayed a biphasic drug release pattern with burst release at the initial stage and prolonged release afterwards, and the successful controlled release rate can be achieved by controlling the liquid lipid content.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China
WOS记录号: WOS:000274722800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62891
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Coll Pharm, Dept Med Chem, Jinan 250012, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Jia, Le-Jiao,Zhang, Dian-Rui,Li, Zhen-Yu,et al. Preparation and characterization of silybin-loaded nanostructured lipid carriers[J]. DRUG DELIVERY,2010,17(1):11-18.
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