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Preparation and characterization of silybin-loaded nanostructured lipid carriers
Jia, Le-Jiao1; Zhang, Dian-Rui1; Li, Zhen-Yu2; Feng, Fei-Fei1; Wang, Yan-Cai1; Dai, Weil-Ting1; Duan, Cun-Xian1; Zhang, Qiang3
关键词Nanostructured lipid carriers Silybin differential scanning calorimetry X-ray diffraction in vitro release
刊名DRUG DELIVERY
2010
DOI10.3109/10717540903431586
17期:1页:11-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]NANOPARTICLES SLN ; ELECTRON-MICROSCOPY ; BODY DISTRIBUTION ; MILK THISTLE ; SPECTROSCOPY ; DELIVERY ; MARIANUM ; SYSTEM ; NLC
英文摘要

Nanostructured lipid carriers (NLC) are a new generation of lipid nanoparticles, which are produced by controlled mixing of solid lipids with spatially incompatible liquid lipids leading to special nanostructures with improved drug incorporation and release properties. In this study, silybin-loaded nanostructured lipid carriers with various liquid lipid content were successfully prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The size and morphology of nanoparticles were significantly influenced by the liquid lipid content. As the liquid lipid content increased to 20 wt%, the obtained particles showed distinguished smaller size. Compared with solid lipid nanoparticles (SLN), NLC presented improved drug loading capacity which increased with increasing the liquid lipid content. The differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis indicated that the incorporation of liquid lipids could interfere with the crystallization of solid lipids. The drug in vitro release behavior from NLC displayed a biphasic drug release pattern with burst release at the initial stage and prolonged release afterwards, and the successful controlled release rate can be achieved by controlling the liquid lipid content.

语种英语
WOS记录号WOS:000274722800002
项目编号2009CB930300
资助机构National Basic Research Program of China
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62891
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Coll Pharm, Dept Med Chem, Jinan 250012, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Jia, Le-Jiao,Zhang, Dian-Rui,Li, Zhen-Yu,et al. Preparation and characterization of silybin-loaded nanostructured lipid carriers[J]. DRUG DELIVERY,2010,17(1):11-18.
APA Jia, Le-Jiao.,Zhang, Dian-Rui.,Li, Zhen-Yu.,Feng, Fei-Fei.,Wang, Yan-Cai.,...&Zhang, Qiang.(2010).Preparation and characterization of silybin-loaded nanostructured lipid carriers.DRUG DELIVERY,17(1),11-18.
MLA Jia, Le-Jiao,et al."Preparation and characterization of silybin-loaded nanostructured lipid carriers".DRUG DELIVERY 17.1(2010):11-18.
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