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Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice
Yu, Lu-lu1,3; Wang, Xue-yi1,3; Zhao, Mei2; Liu, Yu2; Li, Yan-qin2; Li, Fang-qiong2; Wang, Xiaoyi2; Xue, Yan-xue2; Lu, Lin2
关键词Cannabinoid CB1 receptor antagonist Conditioned place preference Methamphetamine Consolidation Reconsolidation
刊名PSYCHOPHARMACOLOGY
2009-06-01
DOI10.1007/s00213-008-1450-y
204期:2页:203-211
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CONDITIONED PLACE PREFERENCE ; FEAR-POTENTIATED STARTLE ; DRUG-ABUSE ; MOTIVATIONAL PROPERTIES ; BASOLATERAL AMYGDALA ; NUCLEUS-ACCUMBENS ; COCAINE ADDICTION ; PROTEIN-SYNTHESIS ; RATS ; BRAIN
英文摘要

Previous studies have shown that cannabinoid CB1 receptors play an important role in specific aspects of learning and memory, yet there has been no systematic study focusing on the involvement of cannabinoid CB1 receptors in methamphetamine-related reward memory.

The purpose of this study was to examine whether rimonabant, a cannabinoid CB1 receptor antagonist, would disrupt the consolidation and reconsolidation of methamphetamine-related reward memory, using conditioned place preference paradigm (CPP).

Separate groups of male Kunming mice were trained to acquire methamphetamine CPP. Vehicle or rimonabant (1 mg/kg or 3 mg/kg, i.p.) was given at different time points: immediately after each CPP training session (consolidation), 30 min before the reactivation of CPP (retrieval), or immediately after the reactivation of CPP (reconsolidation). Methamphetamine CPP was retested 24 h and 1 and 2 weeks after rimonabant administration.

Rimonabant at doses of 1 and 3 mg/kg significantly inhibited the consolidation of methamphetamine CPP. Only high-dose rimonabant (3 mg/kg) disrupted the retrieval and reconsolidation of methamphetamine CPP. Rimonabant had no effect on methamphetamine CPP in the absence of methamphetamine CPP reactivation.

Our findings suggest that cannabinoid CB1 receptors play a major role in methamphetamine reward memory, and cannabinoid CB1 receptor antagonists may be a potential pharmacotherapy to manage relapse associated with drug-reward-related memory.

语种英语
WOS记录号WOS:000265569900002
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62897
专题北京大学第三临床医学院_老年内科
中国药物依赖性研究所
作者单位1.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang 050031, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
3.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang 050031, Peoples R China
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GB/T 7714
Yu, Lu-lu,Wang, Xue-yi,Zhao, Mei,et al. Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice[J]. PSYCHOPHARMACOLOGY,2009,204(2):203-211.
APA Yu, Lu-lu.,Wang, Xue-yi.,Zhao, Mei.,Liu, Yu.,Li, Yan-qin.,...&Lu, Lin.(2009).Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice.PSYCHOPHARMACOLOGY,204(2),203-211.
MLA Yu, Lu-lu,et al."Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice".PSYCHOPHARMACOLOGY 204.2(2009):203-211.
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