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学科主题: 药物依赖
题名:
Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice
作者: Yu, Lu-lu1,3; Wang, Xue-yi1,3; Zhao, Mei2; Liu, Yu2; Li, Yan-qin2; Li, Fang-qiong2; Wang, Xiaoyi2; Xue, Yan-xue2; Lu, Lin2
关键词: Cannabinoid CB1 receptor antagonist ; Conditioned place preference ; Methamphetamine ; Consolidation ; Reconsolidation
刊名: PSYCHOPHARMACOLOGY
发表日期: 2009-06-01
DOI: 10.1007/s00213-008-1450-y
卷: 204, 期:2, 页:203-211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; FEAR-POTENTIATED STARTLE ; DRUG-ABUSE ; MOTIVATIONAL PROPERTIES ; BASOLATERAL AMYGDALA ; NUCLEUS-ACCUMBENS ; COCAINE ADDICTION ; PROTEIN-SYNTHESIS ; RATS ; BRAIN
英文摘要:

Previous studies have shown that cannabinoid CB1 receptors play an important role in specific aspects of learning and memory, yet there has been no systematic study focusing on the involvement of cannabinoid CB1 receptors in methamphetamine-related reward memory.

The purpose of this study was to examine whether rimonabant, a cannabinoid CB1 receptor antagonist, would disrupt the consolidation and reconsolidation of methamphetamine-related reward memory, using conditioned place preference paradigm (CPP).

Separate groups of male Kunming mice were trained to acquire methamphetamine CPP. Vehicle or rimonabant (1 mg/kg or 3 mg/kg, i.p.) was given at different time points: immediately after each CPP training session (consolidation), 30 min before the reactivation of CPP (retrieval), or immediately after the reactivation of CPP (reconsolidation). Methamphetamine CPP was retested 24 h and 1 and 2 weeks after rimonabant administration.

Rimonabant at doses of 1 and 3 mg/kg significantly inhibited the consolidation of methamphetamine CPP. Only high-dose rimonabant (3 mg/kg) disrupted the retrieval and reconsolidation of methamphetamine CPP. Rimonabant had no effect on methamphetamine CPP in the absence of methamphetamine CPP reactivation.

Our findings suggest that cannabinoid CB1 receptors play a major role in methamphetamine reward memory, and cannabinoid CB1 receptor antagonists may be a potential pharmacotherapy to manage relapse associated with drug-reward-related memory.

语种: 英语
所属项目编号: 2007CB512302 ; 2009CB522004 ; 2006AA02Z4D1 ; 30670713 ; 30725016
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000265569900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62897
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang 050031, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
3.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang 050031, Peoples R China

Recommended Citation:
Yu, Lu-lu,Wang, Xue-yi,Zhao, Mei,et al. Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice[J]. PSYCHOPHARMACOLOGY,2009,204(2):203-211.
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