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学科主题: 药物依赖
题名:
Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats
作者: Shi, Hai-Shui1,2; Luo, Yi-Xiao1; Xue, Yan-Xue1; Wu, Ping1; Zhu, Wei-Li1; Ding, Zeng-Bo1; Lu, Lin1
关键词: Morphine ; Memory ; Reconsolidation ; Retrieval ; Sleep deprivation
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2011-04-01
DOI: 10.1016/j.pbb.2011.01.006
卷: 98, 期:2, 页:299-303
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; AFFECTS EXTINCTION ; COCAINE-SEEKING ; DRUG MEMORY ; CONSOLIDATION ; AMYGDALA ; DISRUPTION ; ADDICTION ; EXPRESSION ; STRESS
英文摘要:

Relapse induced by exposure to cues associated with drugs of abuse is a major challenge to the treatment of drug addiction. Drug seeking can be inhibited by manipulation of the reconsolidation of drug-related memory. Sleep has been proposed to be involved in various memory processes. However, the role of sleep in drug reward memory is not clear. The present study used conditioned place preference to examine the effects of total sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats. Six-hour total sleep deprivation had no effect on the retrieval of morphine reward memory. However, sleep deprivation from 0-6 h, but not 6-12 h, after re-exposure disrupted the reconsolidation of morphine reward memory. This impairment was not attributable to the formation of an aversive associative memory between the drug-paired context and sleep deprivation. Our findings suggest that sleep plays a critical role in morphine reward memory reconsolidation, and sleep deprivation may be a potential non-pharmacotherapy for the management of relapse associated with drug-related memory. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30725016 ; 09G0762
项目资助者: Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
WOS记录号: WOS:000289396300020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62898
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China

Recommended Citation:
Shi, Hai-Shui,Luo, Yi-Xiao,Xue, Yan-Xue,et al. Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,98(2):299-303.
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