IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats
Shi, Hai-Shui1,2; Luo, Yi-Xiao1; Xue, Yan-Xue1; Wu, Ping1; Zhu, Wei-Li1; Ding, Zeng-Bo1; Lu, Lin1
关键词Morphine Memory Reconsolidation Retrieval Sleep deprivation
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2011-04-01
DOI10.1016/j.pbb.2011.01.006
98期:2页:299-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]CONDITIONED PLACE PREFERENCE ; AFFECTS EXTINCTION ; COCAINE-SEEKING ; DRUG MEMORY ; CONSOLIDATION ; AMYGDALA ; DISRUPTION ; ADDICTION ; EXPRESSION ; STRESS
英文摘要

Relapse induced by exposure to cues associated with drugs of abuse is a major challenge to the treatment of drug addiction. Drug seeking can be inhibited by manipulation of the reconsolidation of drug-related memory. Sleep has been proposed to be involved in various memory processes. However, the role of sleep in drug reward memory is not clear. The present study used conditioned place preference to examine the effects of total sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats. Six-hour total sleep deprivation had no effect on the retrieval of morphine reward memory. However, sleep deprivation from 0-6 h, but not 6-12 h, after re-exposure disrupted the reconsolidation of morphine reward memory. This impairment was not attributable to the formation of an aversive associative memory between the drug-paired context and sleep deprivation. Our findings suggest that sleep plays a critical role in morphine reward memory reconsolidation, and sleep deprivation may be a potential non-pharmacotherapy for the management of relapse associated with drug-related memory. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000289396300020
项目编号30725016 ; 09G0762
资助机构Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62898
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China
推荐引用方式
GB/T 7714
Shi, Hai-Shui,Luo, Yi-Xiao,Xue, Yan-Xue,et al. Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,98(2):299-303.
APA Shi, Hai-Shui.,Luo, Yi-Xiao.,Xue, Yan-Xue.,Wu, Ping.,Zhu, Wei-Li.,...&Lu, Lin.(2011).Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,98(2),299-303.
MLA Shi, Hai-Shui,et al."Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 98.2(2011):299-303.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Hai-Shui]的文章
[Luo, Yi-Xiao]的文章
[Xue, Yan-Xue]的文章
百度学术
百度学术中相似的文章
[Shi, Hai-Shui]的文章
[Luo, Yi-Xiao]的文章
[Xue, Yan-Xue]的文章
必应学术
必应学术中相似的文章
[Shi, Hai-Shui]的文章
[Luo, Yi-Xiao]的文章
[Xue, Yan-Xue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。