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学科主题: 临床医学
题名:
Age, Arterial Stiffness, and Components of Blood Pressure in Chinese Adults
作者: Zheng, Meili1; Xu, Xiping2; Wang, Xiaobin3; Huo, Yong4; Xu, Xin2; Qin, Xianhui2; Tang, Genfu5; Xing, Houxun5; Fan, Fangfang4; Cui, Wei5; Yang, Xinchun1
刊名: MEDICINE
发表日期: 2014-12-01
DOI: 10.1097/MD.0000000000000262
卷: 93, 期:29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PULSE-WAVE VELOCITY ; ISOLATED SYSTOLIC HYPERTENSION ; ALL-CAUSE MORTALITY ; BRACHIAL-ANKLE ; AORTIC STIFFNESS ; CARDIOVASCULAR EVENTS ; INDEPENDENT PREDICTOR ; INCIDENT HYPERTENSION ; DETERMINANTS ; METAANALYSIS
英文摘要:

Blood pressure (BP) changes with age. We conducted a cross-sectional study in rural Chinese adults to investigate: (1) what is the relationship between age, arterial stiffness, and BP in Chinese men and women; and (2) to what degree can the age-BP relationship be explained by arterial stiffness, controlling for other covariables.

These analyses included a total of 1688 subjects (males/females: 623/1065), aged 40 to 88 years. Among them, 353 (20.9%) had hypertension (defined as systolic blood pressure (SBP) >= 140mm Hg or diastolic blood pressure (DBP) >= 90mm Hg). Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV).

baPWV appeared to be more strongly correlated with BP (including SBP, DBP, mean arterial pressure [ MAP], pulse pressure [ PP]) than age (P < 0.001 for comparisons between Spearman correlation coefficients). Furthermore, baPWV was associated with BP (including SBP, DBP, MAP, and PP) and risk of hypertension in a dose-response fashion, independent of age; in contrast, the age-BP associations were either attenuated or became negative after adjusting for baPWV.

Arterial stiffness appears to be an independent contributor to hypertension, even after adjusting for age and other covariables. In contrast, age-BP associations became attenuated or negative after adjusting for baPWV. The utility of baPWV as a diagnostic, prognostic, and therapeutic indicator for hypertension warrants further investigation.

语种: 英语
WOS记录号: WOS:000346985700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62899
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Capital Med Univ, Beijing Chao Yang Hosp, Ctr Heart, Beijing, Peoples R China
3.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
4.Johns Hopkins Univ, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Bloomberg Sch Publ Hlth, Baltimore, MD USA
5.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Zheng, Meili,Xu, Xiping,Wang, Xiaobin,et al. Age, Arterial Stiffness, and Components of Blood Pressure in Chinese Adults[J]. MEDICINE,2014,93(29).
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